Association between polymorphisms in segregation genes BUB1B and TTK and gastric cancer risk

Abstract

Malignant transformation of normal gastric cells is a complex and multistep process, resulting in development of heterogeneous tumours. Susceptible genetic background, accumulation of genetic changes, and environmental factors play an important role in gastric carcinogenesis. Single nucleotide polymorphisms (SNPs) in mitotic segregation genes could be responsible for inducing the slow process of accumulation of genetic changes, leading to genome instability.

Keywords

• cancer susceptibility
• chromosomal instability
• chromosome segregation
• mitotic checkpoint
• serine/threonine kinase
• genetic association