Nature Communications (Aug 2018)
Genome-wide association study identifies multiple new loci associated with Ewing sarcoma susceptibility
- Mitchell J. Machiela,
- Thomas G. P. Grünewald,
- Didier Surdez,
- Stephanie Reynaud,
- Olivier Mirabeau,
- Eric Karlins,
- Rebeca Alba Rubio,
- Sakina Zaidi,
- Sandrine Grossetete-Lalami,
- Stelly Ballet,
- Eve Lapouble,
- Valérie Laurence,
- Jean Michon,
- Gaelle Pierron,
- Heinrich Kovar,
- Nathalie Gaspar,
- Udo Kontny,
- Anna González-Neira,
- Piero Picci,
- Javier Alonso,
- Ana Patino-Garcia,
- Nadège Corradini,
- Perrine Marec Bérard,
- Neal D. Freedman,
- Nathaniel Rothman,
- Casey L. Dagnall,
- Laurie Burdett,
- Kristine Jones,
- Michelle Manning,
- Kathleen Wyatt,
- Weiyin Zhou,
- Meredith Yeager,
- David G. Cox,
- Robert N. Hoover,
- Javed Khan,
- Gregory T. Armstrong,
- Wendy M. Leisenring,
- Smita Bhatia,
- Leslie L. Robison,
- Andreas E. Kulozik,
- Jennifer Kriebel,
- Thomas Meitinger,
- Markus Metzler,
- Wolfgang Hartmann,
- Konstantin Strauch,
- Thomas Kirchner,
- Uta Dirksen,
- Lindsay M. Morton,
- Lisa Mirabello,
- Margaret A. Tucker,
- Franck Tirode,
- Stephen J. Chanock,
- Olivier Delattre
Affiliations
- Mitchell J. Machiela
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Thomas G. P. Grünewald
- Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU
- Didier Surdez
- Inserm U830, Équipe Labellisés LNCC, PSL Université, Institut Curie
- Stephanie Reynaud
- SIREDO Oncology Centre, Institut Curie
- Olivier Mirabeau
- Inserm U830, Équipe Labellisés LNCC, PSL Université, Institut Curie
- Eric Karlins
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Rebeca Alba Rubio
- Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU
- Sakina Zaidi
- Inserm U830, Équipe Labellisés LNCC, PSL Université, Institut Curie
- Sandrine Grossetete-Lalami
- Inserm U830, Équipe Labellisés LNCC, PSL Université, Institut Curie
- Stelly Ballet
- SIREDO Oncology Centre, Institut Curie
- Eve Lapouble
- SIREDO Oncology Centre, Institut Curie
- Valérie Laurence
- SIREDO Oncology Centre, Institut Curie
- Jean Michon
- SIREDO Oncology Centre, Institut Curie
- Gaelle Pierron
- SIREDO Oncology Centre, Institut Curie
- Heinrich Kovar
- Children’s Cancer Research Institute, St. Anna Kinderkrebsforschung
- Nathalie Gaspar
- Department of Oncology for Child and Adolescent, Institut Gustave Roussy
- Udo Kontny
- Division of Pediatric Hematology Oncology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University
- Anna González-Neira
- Human Genotyping Unit-CeGen, Human Cancer Genetics Programme, Spanish National Cancer Research Centre
- Piero Picci
- Laboratorio di Oncologia Sperimentale, Istituto Ortopedico Rizzoli di Bologna
- Javier Alonso
- Unidad de Tumores Sólidos Infantiles, Instituto de Investigación de Enfermedades Raras, Instituto de Salud Carlos III
- Ana Patino-Garcia
- Laboratory of Pediatrics, University of Navarra, University Clinic of Navarra, IdiSNA
- Nadège Corradini
- Institute for Paediatric Haematology and Oncology, Leon Bérard Cancer Centre, University of Lyon
- Perrine Marec Bérard
- Institute for Paediatric Haematology and Oncology, Leon Bérard Cancer Centre, University of Lyon
- Neal D. Freedman
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Nathaniel Rothman
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Casey L. Dagnall
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Laurie Burdett
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Kristine Jones
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Michelle Manning
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Kathleen Wyatt
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Weiyin Zhou
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Meredith Yeager
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- David G. Cox
- Centre Léon Bérard, INSERM U1052
- Robert N. Hoover
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Javed Khan
- Genetics Branch, Center for Cancer Research, National Cancer Institute
- Gregory T. Armstrong
- Department of Epidemiology and Cancer Control, St. Jude Children’s Research Hospital
- Wendy M. Leisenring
- Cancer Prevention and Clinical Statistics Programs, Fred Hutchinson Cancer Research Center
- Smita Bhatia
- Institute for Cancer Outcomes and Survivorship, University of Alabama
- Leslie L. Robison
- Department of Epidemiology and Cancer Control, St. Jude Children’s Research Hospital
- Andreas E. Kulozik
- University Children’s Hospital of Heidelberg
- Jennifer Kriebel
- Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Thomas Meitinger
- Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health
- Markus Metzler
- University Children’s Hospital of Erlangen
- Wolfgang Hartmann
- Gerhard-Domagk Institute of Pathology, University Hospital of Münster
- Konstantin Strauch
- Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Thomas Kirchner
- German Consortium for Cancer Research (DKTK)
- Uta Dirksen
- University Children’s Hospital of Essen
- Lindsay M. Morton
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Lisa Mirabello
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Margaret A. Tucker
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Franck Tirode
- Inserm U830, Équipe Labellisés LNCC, PSL Université, Institut Curie
- Stephen J. Chanock
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Olivier Delattre
- Inserm U830, Équipe Labellisés LNCC, PSL Université, Institut Curie
- DOI
- https://doi.org/10.1038/s41467-018-05537-2
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 8
Abstract
Ewing sarcoma (EWS) is a rare pediatric bone cancer typically involving the EWSR1-FLI1 fusion. Here the authors perform a genome-wide association study and report three new EWS risk loci that reside near GGAA repeat sequences, and identify candidate genes (RREB1 and KIZ) from eQTL analysis.
