Life-Threatening Adverse Events Following Therapeutic Opioid Administration in Adults: Is Pharmacogenetic Analysis Useful?

Parvaz Madadi; Johanna Sistonen; Gregory Silverman; Rebecca Gladdy; Colin J Ross; Bruce C Carleton; Jose C Carvalho; Michael R Hayden; Gideon Koren

doi:10.1155/2013/518012

Pain Research and Management (Jan 2013)

Life-Threatening Adverse Events Following Therapeutic Opioid Administration in Adults: Is Pharmacogenetic Analysis Useful?

Parvaz Madadi,
Johanna Sistonen,
Gregory Silverman,
Rebecca Gladdy,
Colin J Ross,
Bruce C Carleton,
Jose C Carvalho,
Michael R Hayden,
Gideon Koren

Affiliations

Parvaz Madadi: Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ontario, Canada
Johanna Sistonen: Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada
Gregory Silverman: Department of Anesthesia and Pain Management, Mount Sinai Hospital, Canada
Rebecca Gladdy: Department of Surgery, Mount Sinai Hospital, Toronto, Ontario, Canada
Colin J Ross: Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada
Bruce C Carleton: Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
Jose C Carvalho: Department of Anesthesia and Pain Management, Mount Sinai Hospital, Canada
Michael R Hayden: Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada
Gideon Koren: Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ontario, Canada

DOI: https://doi.org/10.1155/2013/518012
Journal volume & issue: Vol. 18, no. 3
pp. 133 – 136

Abstract

Read online

BACKGROUND: Systemic approaches are needed to understand how variations in the genes associated with opioid pharmacokinetics and response can be used to predict patient outcome. The application of pharmacogenetic analysis to two cases of life-threatening opioid-induced respiratory depression is presented. The usefulness of genotyping in the context of these cases is discussed.

Published in Pain Research and Management

ISSN: 1203-6765 (Print); 1918-1523 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Medicine (General)
Website: https://onlinelibrary.wiley.com/journal/7040

About the journal