Modern concept of the brain-lung-thyroid syndrome and its pulmonary manifestations

Abstract

This article is a review of the modern world literature on the brain-lung-thyroid syndrome in children. The authors focused on the etiology and features of ontogenesis of the involved organs in the presence of NKX2-1 gene mutation. Particular attention is paid to the clinical manifestations and early diagnosis of this syndrome in newborns and young children. Current options for the treatment of the brain-lung-thyroid syndrome are presented.

Keywords

• children
• newborns
• NKX2-1
• TTF-1
• interstitial lung diseases
• respiratory distress syndrome
• brain-lung-thyroid syndrome
• review