Endometrial thickness is an independent risk factor of hypertensive disorders of pregnancy: a retrospective study of 13,458 patients in frozen-thawed embryo transfers

Abstract

Abstract Background Hypertensive disorders of pregnancy (HDP) are an important cause of maternal and fetal mortality, and its potential risk factors are still being explored. Endometrial thickness (EMT), as one of the important monitoring indicators of endometrial receptivity, has been confirmed to be related to the incidence of HDP in fresh embryo transfer. Our study was designed to investigate whether endometrial thickness is associated with the risk of hypertensive disorders of pregnancy in frozen-thawed embryo transfer (FET). Methods This respective cohort study enrolled 13,458 women who received vitrified embryo transfer and had a singleton delivery in the Reproductive Hospital affiliated to Shandong University from January 2015 to December 2019. We set strict screening criteria and obtained the information from the hospital electronic medical system. Statistical methods including logistic regression analysis, receiver operating characteristic curve and restricted cubic spline were used to evaluate the relationship between endometrial thickness and the incidence of pregnancy-induced hypertension. Results The incidences of HDP in a thin endometrial thickness group ( 1.2 cm) were significantly greater than in a reference group (0.8 cm–1.2 cm) (7.98 and 5.24% vs 4.59%, P 1.2 cm) endometrial thickness achieve pregnancy through frozen-thawed embryo transfer.

Keywords

• IVF/ICSI
• FET
• Ultrasound measurements of endometrium thickness
• Natural cycles
• Hormone programmed cycles
• Obstetric complications