Nature Communications (Sep 2018)

Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume

  • Dina Vojinovic,
  • Hieab H. Adams,
  • Xueqiu Jian,
  • Qiong Yang,
  • Albert Vernon Smith,
  • Joshua C. Bis,
  • Alexander Teumer,
  • Markus Scholz,
  • Nicola J. Armstrong,
  • Edith Hofer,
  • Yasaman Saba,
  • Michelle Luciano,
  • Manon Bernard,
  • Stella Trompet,
  • Jingyun Yang,
  • Nathan A. Gillespie,
  • Sven J. van der Lee,
  • Alexander Neumann,
  • Shahzad Ahmad,
  • Ole A. Andreassen,
  • David Ames,
  • Najaf Amin,
  • Konstantinos Arfanakis,
  • Mark E. Bastin,
  • Diane M. Becker,
  • Alexa S. Beiser,
  • Frauke Beyer,
  • Henry Brodaty,
  • R. Nick Bryan,
  • Robin Bülow,
  • Anders M. Dale,
  • Philip L. De Jager,
  • Ian J. Deary,
  • Charles DeCarli,
  • Debra A. Fleischman,
  • Rebecca F. Gottesman,
  • Jeroen van der Grond,
  • Vilmundur Gudnason,
  • Tamara B. Harris,
  • Georg Homuth,
  • David S. Knopman,
  • John B. Kwok,
  • Cora E. Lewis,
  • Shuo Li,
  • Markus Loeffler,
  • Oscar L. Lopez,
  • Pauline Maillard,
  • Hanan El Marroun,
  • Karen A. Mather,
  • Thomas H. Mosley,
  • Ryan L. Muetzel,
  • Matthias Nauck,
  • Paul A. Nyquist,
  • Matthew S. Panizzon,
  • Zdenka Pausova,
  • Bruce M. Psaty,
  • Ken Rice,
  • Jerome I. Rotter,
  • Natalie Royle,
  • Claudia L. Satizabal,
  • Reinhold Schmidt,
  • Peter R. Schofield,
  • Pamela J. Schreiner,
  • Stephen Sidney,
  • David J. Stott,
  • Anbupalam Thalamuthu,
  • Andre G. Uitterlinden,
  • Maria C. Valdés Hernández,
  • Meike W. Vernooij,
  • Wei Wen,
  • Tonya White,
  • A. Veronica Witte,
  • Katharina Wittfeld,
  • Margaret J. Wright,
  • Lisa R. Yanek,
  • Henning Tiemeier,
  • William S. Kremen,
  • David A. Bennett,
  • J. Wouter Jukema,
  • Tomas Paus,
  • Joanna M. Wardlaw,
  • Helena Schmidt,
  • Perminder S. Sachdev,
  • Arno Villringer,
  • Hans Jörgen Grabe,
  • W T Longstreth,
  • Cornelia M. van Duijn,
  • Lenore J. Launer,
  • Sudha Seshadri,
  • M Arfan Ikram,
  • Myriam Fornage

DOI
https://doi.org/10.1038/s41467-018-06234-w
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 11

Abstract

Read online

An increase in the volume of the brain lateral ventricles is a sign of normal aging, but can also be associated with neurological and psychiatric disorders. Here, Vojinovic et al. identify seven genetic loci in a GWA study for ventricular volume in 23,500 individuals and find correlation with thalamus volume.