Nature Communications (Feb 2021)
Improving hindlimb locomotor function by Non-invasive AAV-mediated manipulations of propriospinal neurons in mice with complete spinal cord injury
- Benedikt Brommer,
- Miao He,
- Zicong Zhang,
- Zhiyun Yang,
- Jessica C. Page,
- Junfeng Su,
- Yu Zhang,
- Junjie Zhu,
- Emilia Gouy,
- Jing Tang,
- Philip Williams,
- Wei Dai,
- Qi Wang,
- Ryan Solinsky,
- Bo Chen,
- Zhigang He
Affiliations
- Benedikt Brommer
- F.M. Kirby Neurobiology Center, Boston Children’s Hospital, and Departments of Neurology and Ophthalmology, Harvard Medical School
- Miao He
- F.M. Kirby Neurobiology Center, Boston Children’s Hospital, and Departments of Neurology and Ophthalmology, Harvard Medical School
- Zicong Zhang
- F.M. Kirby Neurobiology Center, Boston Children’s Hospital, and Departments of Neurology and Ophthalmology, Harvard Medical School
- Zhiyun Yang
- F.M. Kirby Neurobiology Center, Boston Children’s Hospital, and Departments of Neurology and Ophthalmology, Harvard Medical School
- Jessica C. Page
- F.M. Kirby Neurobiology Center, Boston Children’s Hospital, and Departments of Neurology and Ophthalmology, Harvard Medical School
- Junfeng Su
- F.M. Kirby Neurobiology Center, Boston Children’s Hospital, and Departments of Neurology and Ophthalmology, Harvard Medical School
- Yu Zhang
- F.M. Kirby Neurobiology Center, Boston Children’s Hospital, and Departments of Neurology and Ophthalmology, Harvard Medical School
- Junjie Zhu
- F.M. Kirby Neurobiology Center, Boston Children’s Hospital, and Departments of Neurology and Ophthalmology, Harvard Medical School
- Emilia Gouy
- F.M. Kirby Neurobiology Center, Boston Children’s Hospital, and Departments of Neurology and Ophthalmology, Harvard Medical School
- Jing Tang
- F.M. Kirby Neurobiology Center, Boston Children’s Hospital, and Departments of Neurology and Ophthalmology, Harvard Medical School
- Philip Williams
- F.M. Kirby Neurobiology Center, Boston Children’s Hospital, and Departments of Neurology and Ophthalmology, Harvard Medical School
- Wei Dai
- F.M. Kirby Neurobiology Center, Boston Children’s Hospital, and Departments of Neurology and Ophthalmology, Harvard Medical School
- Qi Wang
- F.M. Kirby Neurobiology Center, Boston Children’s Hospital, and Departments of Neurology and Ophthalmology, Harvard Medical School
- Ryan Solinsky
- Spaulding Rehabilitation Hospital
- Bo Chen
- Department of Neuroscience, Cell Biology, & Anatomy, University of Texas Medical Branch
- Zhigang He
- F.M. Kirby Neurobiology Center, Boston Children’s Hospital, and Departments of Neurology and Ophthalmology, Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-021-20980-4
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
After complete spinal cord injury, spinal segments below the lesion maintain inter-segmental communication via the intraspinal propriospinal network. Here, the authors show that neurons in these circuits can be chemogenetically modulated to improve locomotor function in mice after spinal cord injury.
