Neurobiology of Disease (Mar 2019)
The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocol
- Paul M. Vespa,
- Vikesh Shrestha,
- Nicholas Abend,
- Denes Agoston,
- Alicia Au,
- Michael J. Bell,
- Thomas P. Bleck,
- Manuel Buitrago Blanco,
- Jan Claassen,
- Ramon Diaz-Arrastia,
- Dominique Duncan,
- Ben Ellingson,
- Brandon Foreman,
- Emily J. Gilmore,
- Lawrence Hirsch,
- Martin Hunn,
- Alaa Kamnaksh,
- David McArthur,
- Andrew Morokoff,
- Terrence O'Brien,
- Kristine O'Phelan,
- Courtney L. Robertson,
- Eric Rosenthal,
- Richard Staba,
- Arthur Toga,
- Frederick A. Willyerd,
- Lara Zimmermann,
- Elisa Yam,
- Susana Martinez,
- Courtney Real,
- Jerome Engel, Jr
Affiliations
- Paul M. Vespa
- David Geffen School of Medicine at UCLA, United States; Corresponding author at: David Geffen School of Medicine at UCLA, 757 Westwood Blvd, Ronald Reagan Medical Center, 6236A Los Angeles, United States.
- Vikesh Shrestha
- David Geffen School of Medicine at UCLA, United States
- Nicholas Abend
- University of Pennsylvania, United States
- Denes Agoston
- Uniformed Services University, United States
- Alicia Au
- University of Pittsburgh, United States
- Michael J. Bell
- Children's National Health System, United States
- Thomas P. Bleck
- Rush University, United States
- Manuel Buitrago Blanco
- David Geffen School of Medicine at UCLA, United States
- Jan Claassen
- Columbia University, United States
- Ramon Diaz-Arrastia
- University of Pennsylvania, United States
- Dominique Duncan
- University of Southern California, United States
- Ben Ellingson
- David Geffen School of Medicine at UCLA, United States
- Brandon Foreman
- University of Cincinnati, United States
- Emily J. Gilmore
- Yale University, United States
- Lawrence Hirsch
- Yale University, United States
- Martin Hunn
- The Alfred Hospital Melbourne, Australia
- Alaa Kamnaksh
- Uniformed Services University, United States
- David McArthur
- David Geffen School of Medicine at UCLA, United States
- Andrew Morokoff
- Royal Melbourne Hospital, United States
- Terrence O'Brien
- Royal Melbourne Hospital, United States
- Kristine O'Phelan
- University of Miami, United States
- Courtney L. Robertson
- Johns Hopkins University, United States
- Eric Rosenthal
- Harvard University/Massachusetts General Hospital, United States
- Richard Staba
- David Geffen School of Medicine at UCLA, United States
- Arthur Toga
- University of Southern California, United States
- Frederick A. Willyerd
- Phoenix Children's Hospital, United States
- Lara Zimmermann
- University of California, Davis, United States
- Elisa Yam
- David Geffen School of Medicine at UCLA, United States
- Susana Martinez
- David Geffen School of Medicine at UCLA, United States
- Courtney Real
- David Geffen School of Medicine at UCLA, United States
- Jerome Engel, Jr
- David Geffen School of Medicine at UCLA, United States
- Journal volume & issue
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Vol. 123
pp. 110 – 114
Abstract
The Epilepsy Bioinformatics Study for Anti-epileptogenic Therapy (EpiBioS4Rx) is a longitudinal prospective observational study funded by the National Institute of Health (NIH) to discover and validate observational biomarkers of epileptogenesis after traumatic brain injury (TBI). A multidisciplinary approach has been incorporated to investigate acute electrical, neuroanatomical, and blood biomarkers after TBI that may predict the development of post-traumatic epilepsy (PTE). We plan to enroll 300 moderate-severe TBI patients with a frontal and/or temporal lobe hemorrhagic contusion. Acute evaluation with blood, imaging and electroencephalographic monitoring will be performed and then patients will be tracked for 2 years to determine the incidence of PTE. Validation of selected biomarkers that are discovered in planned animal models will be a principal feature of this work. Specific hypotheses regarding the discovery of biomarkers have been set forth in this study. An international cohort of 13 centers spanning 2 continents will be developed to facilitate this study, and for future interventional studies.
