Src family kinases, adaptor proteins and the actin cytoskeleton in epithelial-to-mesenchymal transition

Abstract

Abstract Over a century of scientific inquiry since the discovery of v-SRC but still no final judgement on SRC function. However, a significant body of work has defined Src family kinases as key players in tumor progression, invasion and metastasis in human cancer. With the ever-growing evidence supporting the role of epithelial-mesenchymal transition (EMT) in invasion and metastasis, so does our understanding of the role SFKs play in mediating these processes. Here we describe some key mechanisms through which Src family kinases play critical role in epithelial homeostasis and how their function is essential for the propagation of invasive signals. Video abstract

Keywords

• Src family kinases
• Epithelial-to-mesenchymal transition
• Treatment resistance
• Metastasis
• Invasion
• Unique domain