Synthesis of N-substituted phthalimidoalkyl 1,2,3-triazoles via click chemistry

Abstract

In the present work, we have developed a facile procedure for synthesis of new N-phthalimidoalkyl 1H-1,2,3-Triazoles (1-4)(a-h) using DMF, 10 mol% CuI, Et3N and ultrasound energy at room temperature. This protocol furnished 28 new compounds in 20 to 30 min of reaction and moderate-to-excellent yields (64-94%).

Keywords

• triazole
• ultrasound
• phthalimide