Nature Communications (Feb 2020)
APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy
- Christopher B. Driscoll,
- Matthew R. Schuelke,
- Timothy Kottke,
- Jill M. Thompson,
- Phonphimon Wongthida,
- Jason M. Tonne,
- Amanda L. Huff,
- Amber Miller,
- Kevin G. Shim,
- Amy Molan,
- Cynthia Wetmore,
- Peter Selby,
- Adel Samson,
- Kevin Harrington,
- Hardev Pandha,
- Alan Melcher,
- Jose S. Pulido,
- Reuben Harris,
- Laura Evgin,
- Richard G. Vile
Affiliations
- Christopher B. Driscoll
- Department of Molecular Medicine, Mayo Clinic
- Matthew R. Schuelke
- Department of Molecular Medicine, Mayo Clinic
- Timothy Kottke
- Department of Molecular Medicine, Mayo Clinic
- Jill M. Thompson
- Department of Molecular Medicine, Mayo Clinic
- Phonphimon Wongthida
- Department of Molecular Medicine, Mayo Clinic
- Jason M. Tonne
- Department of Molecular Medicine, Mayo Clinic
- Amanda L. Huff
- Department of Molecular Medicine, Mayo Clinic
- Amber Miller
- Department of Molecular Medicine, Mayo Clinic
- Kevin G. Shim
- Department of Molecular Medicine, Mayo Clinic
- Amy Molan
- Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota
- Cynthia Wetmore
- Center for Cancer and Blood Disorders, Phoenix Children’s
- Peter Selby
- Leeds Institute of Cancer and Pathology (LICAP), Faculty of Medicine and Health, St James’ University Hospital, University of Leeds
- Adel Samson
- Leeds Institute of Cancer and Pathology (LICAP), Faculty of Medicine and Health, St James’ University Hospital, University of Leeds
- Kevin Harrington
- Targeted Therapy Team, Division of Radiotherapy and Imaging, The Institute of Cancer Research
- Hardev Pandha
- Postgraduate Medical School, University of Surrey
- Alan Melcher
- Translational Immunotherapy Team, Division of Radiotherapy and Imaging, The Institute of Cancer Research
- Jose S. Pulido
- Department of Ophthalmology, Mayo Clinic
- Reuben Harris
- Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota
- Laura Evgin
- Department of Molecular Medicine, Mayo Clinic
- Richard G. Vile
- Department of Molecular Medicine, Mayo Clinic
- DOI
- https://doi.org/10.1038/s41467-020-14568-7
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
DNA mutations induced by dysregulated APOBEC3 expression are associated with tumour-progression and therapeutic resistance, but also with the generation of neoepitopes. Here, the authors show that APOBEC3 function can be exploited in a vaccine setting to generate heteroclitic neoepitopes, enhancing sensitivity to immunotherapy.
