Intratumoral injection of TLR9 agonist promotes an immunopermissive microenvironment transition and causes cooperative antitumor activity in combination with anti-PD1 in pancreatic cancer

• Paola Cappello,
• Maurizio Martini,
• Aldo Scarpa,
• Stefano Ugel,
• Francesco De Sanctis,
• Giampaolo Tortora,
• Emilio Bria,
• Vincenzo Corbo,
• Carmine Carbone,
• Geny Piro,
• Antonio Agostini,
• Pietro Delfino,
• Vincenzo Nasca,
• Francesco Spallotta,
• Claudio Sette

Affiliations

Paola Cappello

Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy

Maurizio Martini

Division of Anatomic Pathology and Histology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy

Aldo Scarpa

Department of Diagnostics and Public Health, University and Hospital Trust of Verona, Verona, Italy

Stefano Ugel

Department of Medicine, Section of Immunology, University of Verona, Verona, Italy

Francesco De Sanctis

Department of Medicine, Section of Immunology, University of Verona, Verona, Italy

Giampaolo Tortora

Medical Oncology, Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy

Emilio Bria

Medical Oncology, Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy

Vincenzo Corbo

Department of Diagnostics and Public Health, University and Hospital Trust of Verona, Verona, Italy

Carmine Carbone

Medical Oncology, Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy

Geny Piro

Medical Oncology, Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy

Antonio Agostini

Medical Oncology, Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy

Pietro Delfino

Department of Diagnostics and Public Health, University and Hospital Trust of Verona, Verona, Italy

Vincenzo Nasca

Medical Oncology, Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy

Francesco Spallotta

Institute for Systems Analysis and Computer Science “A. Ruberti”, National Research Council (IASI – CNR), Rome, Italy

Claudio Sette

Department of Neuroscience, Catholic University of the Sacred Heart, Milano, Italy