Anticancer Activity In Vitro of Sulfated Polysaccharides from the Brown Alga <i>Spatoglossum vietnamense</i>

Dinh Thanh Trung; Valerii Victorovich Surits; Anastasia Olegovna Zueva; Hang Thi Thuy Cao; Natalia Michailovna Shevchenko; Svetlana Pavlovna Ermakova; Pham Duc Thinh

doi:10.3390/molecules29214982

Molecules (Oct 2024)

Anticancer Activity In Vitro of Sulfated Polysaccharides from the Brown Alga <i>Spatoglossum vietnamense</i>

Dinh Thanh Trung,
Valerii Victorovich Surits,
Anastasia Olegovna Zueva,
Hang Thi Thuy Cao,
Natalia Michailovna Shevchenko,
Svetlana Pavlovna Ermakova,
Pham Duc Thinh

Affiliations

Dinh Thanh Trung: Nhatrang Institute of Technology Research and Application, Vietnam Academy of Science and Technology, Nha Trang 650000, Vietnam
Valerii Victorovich Surits: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, 690022 Vladivostok, Russia
Anastasia Olegovna Zueva: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, 690022 Vladivostok, Russia
Hang Thi Thuy Cao: Nhatrang Institute of Technology Research and Application, Vietnam Academy of Science and Technology, Nha Trang 650000, Vietnam
Natalia Michailovna Shevchenko: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, 690022 Vladivostok, Russia
Svetlana Pavlovna Ermakova: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, 690022 Vladivostok, Russia
Pham Duc Thinh: Nhatrang Institute of Technology Research and Application, Vietnam Academy of Science and Technology, Nha Trang 650000, Vietnam

DOI: https://doi.org/10.3390/molecules29214982
Journal volume & issue: Vol. 29, no. 21
p. 4982

Abstract

Read online

Sulfated polysaccharides SpvF1, SpvF2, SpvF3, and SpvF4 from the brown alga S. vietnamense collected north of Hon Do (Nha Trang Bay, Vietnam) were isolated and studied. The structure of the obtained polysaccharide was studied using chemical methods and NMR spectroscopy. Fucoidans were low-sulfated (SpvF1, SpvF2) and medium-sulfated (SpvF3, SpvF4) heterogeneous polysaccharides. The molecular weight of the polysaccharides obtained was in the range of 16 to 44 kDa. All investigated fucoidans until 400 µg/mL were not cytotoxic for human colon carcinoma cells DLD-1, HCT-116, and HT-29 in vitro. Fucoidans SpvF1 and SpvF2 have inhibited the colony formation and growth of investigated cells from 20 to 30%. Fucoidans SpvF3 and SpvF4 have the strongest inhibitory effect for investigated cancer cells: from 40 to 50%.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

About the journal

Abstract

Keywords