Journal of Pain Research (Dec 2022)
Modeling the Impact of the Variation in Peripheral Nerve Anatomy on Stimulation
Abstract
Lakshmi Narayan Mishra,1 Gaurav Kulkarni,2 Mandar Gadgil2 1Nalu Medical Inc., Carlsbad, CA, USA; 2Oneirix Engineering Laboratories Pvt. Ltd., Pune, MH, IndiaCorrespondence: Lakshmi Narayan Mishra, Nalu Medical Inc., 2320 Faraday Avenue, Suite 100, Carlsbad, CA, 92008, USA, Tel +1 760-448-2360, Email [email protected]: The peripheral nervous system has a complex anatomical structure. Stimulation of nerve fibers in the peripheral nervous system depends on the fiber diameter and myelination as well as its location within the nerve, packing fraction and fascicle distribution within the nerve bundle. This paper analyzes the impact of the variation in peripheral nervous system anatomy and the distance of the stimulating electrodes on the probability of generating an action potential.Methods: A mathematical model for effective fascicle conductivity has been developed to capture the variation in the packing fraction and fiber diameter. A linear activating function is utilized to analyze the impact of this effective conductivity and fascicle distribution as an indicator of generating an action potential.Results: Finite element simulations are performed for the nerve-electrode configuration to evaluate the electric field. The simulation results are used to analyze the activating function for different packing fractions and type of nerve fibers. The effect of electrode distance on activating function and the total current through a nerve bundle has also been studied.Discussion: The simulation results indicate that the peripheral nerve anatomy and electrode distance have a significant effect on the action potential generation.Keywords: peripheral nerve stimulation, packing fraction, computational modeling, fascicle distribution, activating function
