Community science designed ribosomes with beneficial phenotypes

Antje Krüger; Andrew M. Watkins; Roger Wellington-Oguri; Jonathan Romano; Camila Kofman; Alysse DeFoe; Yejun Kim; Jeff Anderson-Lee; Eli Fisker; Jill Townley; Eterna Participants; Anne E. d’Aquino; Rhiju Das; Michael C. Jewett

doi:10.1038/s41467-023-35827-3

Nature Communications (Feb 2023)

Community science designed ribosomes with beneficial phenotypes

Antje Krüger,
Andrew M. Watkins,
Roger Wellington-Oguri,
Jonathan Romano,
Camila Kofman,
Alysse DeFoe,
Yejun Kim,
Jeff Anderson-Lee,
Eli Fisker,
Jill Townley,
Eterna Participants,
Anne E. d’Aquino,
Rhiju Das,
Michael C. Jewett

Affiliations

Antje Krüger: Department of Chemical and Biological Engineering, Chemistry of Life Processes Institute, and Center for Synthetic Biology, Northwestern University
Andrew M. Watkins: Department of Biochemistry, Stanford University
Roger Wellington-Oguri: Eterna Massive Open Laboratory
Jonathan Romano: Department of Biochemistry, Stanford University
Camila Kofman: Department of Chemical and Biological Engineering, Chemistry of Life Processes Institute, and Center for Synthetic Biology, Northwestern University
Alysse DeFoe: Department of Chemical and Biological Engineering, Chemistry of Life Processes Institute, and Center for Synthetic Biology, Northwestern University
Yejun Kim: Department of Chemical and Biological Engineering, Chemistry of Life Processes Institute, and Center for Synthetic Biology, Northwestern University
Jeff Anderson-Lee: Eterna Massive Open Laboratory
Eli Fisker: Eterna Massive Open Laboratory
Jill Townley: Eterna Massive Open Laboratory
Eterna Participants
Anne E. d’Aquino: Department of Chemical and Biological Engineering, Chemistry of Life Processes Institute, and Center for Synthetic Biology, Northwestern University
Rhiju Das: Department of Biochemistry, Stanford University
Michael C. Jewett: Department of Chemical and Biological Engineering, Chemistry of Life Processes Institute, and Center for Synthetic Biology, Northwestern University

DOI: https://doi.org/10.1038/s41467-023-35827-3
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 11

Abstract

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While the ribosome has been harnessed for synthetic biology, designing ribosomes has remained challenging. Here, the authors demonstrate a community science approach for rational design of ribosomes with beneficial properties.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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