Nature Communications (Mar 2018)
Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors
- Julie George,
- Vonn Walter,
- Martin Peifer,
- Ludmil B. Alexandrov,
- Danila Seidel,
- Frauke Leenders,
- Lukas Maas,
- Christian Müller,
- Ilona Dahmen,
- Tiffany M. Delhomme,
- Maude Ardin,
- Noemie Leblay,
- Graham Byrnes,
- Ruping Sun,
- Aurélien De Reynies,
- Anne McLeer-Florin,
- Graziella Bosco,
- Florian Malchers,
- Roopika Menon,
- Janine Altmüller,
- Christian Becker,
- Peter Nürnberg,
- Viktor Achter,
- Ulrich Lang,
- Peter M. Schneider,
- Magdalena Bogus,
- Matthew G. Soloway,
- Matthew D. Wilkerson,
- Yupeng Cun,
- James D. McKay,
- Denis Moro-Sibilot,
- Christian G. Brambilla,
- Sylvie Lantuejoul,
- Nicolas Lemaitre,
- Alex Soltermann,
- Walter Weder,
- Verena Tischler,
- Odd Terje Brustugun,
- Marius Lund-Iversen,
- Åslaug Helland,
- Steinar Solberg,
- Sascha Ansén,
- Gavin Wright,
- Benjamin Solomon,
- Luca Roz,
- Ugo Pastorino,
- Iver Petersen,
- Joachim H. Clement,
- Jörg Sänger,
- Jürgen Wolf,
- Martin Vingron,
- Thomas Zander,
- Sven Perner,
- William D. Travis,
- Stefan A. Haas,
- Magali Olivier,
- Matthieu Foll,
- Reinhard Büttner,
- David Neil Hayes,
- Elisabeth Brambilla,
- Lynnette Fernandez-Cuesta,
- Roman K. Thomas
Affiliations
- Julie George
- Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne
- Vonn Walter
- UNC Lineberger Comprehensive Cancer Center School of Medicine, University of North Carolina at Chapel Hill
- Martin Peifer
- Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne
- Ludmil B. Alexandrov
- Department of Cellular and Molecular Medicine and Department of Bioengineering and Moores Cancer Center, University of California
- Danila Seidel
- Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne
- Frauke Leenders
- Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne
- Lukas Maas
- Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne
- Christian Müller
- Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne
- Ilona Dahmen
- Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne
- Tiffany M. Delhomme
- Genetic Cancer Susceptibility Group, Section of Genetics, International Agency for Research on Cancer (IARC-WHO)
- Maude Ardin
- Molecular Mechanisms and Biomarkers Group, Section of Mechanisms of Carcinogenesis, International Agency for Research on Cancer (IARC-WHO)
- Noemie Leblay
- Genetic Cancer Susceptibility Group, Section of Genetics, International Agency for Research on Cancer (IARC-WHO)
- Graham Byrnes
- Section of Environment and Radiation, International Agency for Research on Cancer (IARC-WHO)
- Ruping Sun
- Computational Molecular Biology Group, Max Planck Institute for Molecular Genetics
- Aurélien De Reynies
- Programme Cartes d’Identité des Tumeurs (CIT), Ligue Nationale Contre le Cancer
- Anne McLeer-Florin
- CHU Grenoble Alpes, UGA/INSERM U1209/CNRS
- Graziella Bosco
- Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne
- Florian Malchers
- Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne
- Roopika Menon
- NEO New Oncology GmbH
- Janine Altmüller
- Center for Molecular Medicine Cologne (CMMC), University of Cologne
- Christian Becker
- Cologne Center for Genomics (CCG), University of Cologne
- Peter Nürnberg
- Center for Molecular Medicine Cologne (CMMC), University of Cologne
- Viktor Achter
- Computing Center, University of Cologne
- Ulrich Lang
- Computing Center, University of Cologne
- Peter M. Schneider
- Institute of Legal Medicine, University Hospital Cologne
- Magdalena Bogus
- Institute of Legal Medicine, University Hospital Cologne
- Matthew G. Soloway
- UNC Lineberger Comprehensive Cancer Center School of Medicine, University of North Carolina at Chapel Hill
- Matthew D. Wilkerson
- Department of Genetics, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill
- Yupeng Cun
- Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne
- James D. McKay
- Genetic Cancer Susceptibility Group, Section of Genetics, International Agency for Research on Cancer (IARC-WHO)
- Denis Moro-Sibilot
- CHUGA Grenoble, INSERM U 1209, University Grenoble Alpes, Institute of Advanced Biosciences (IAB), 38043
- Christian G. Brambilla
- CHUGA Grenoble, INSERM U 1209, University Grenoble Alpes, Institute of Advanced Biosciences (IAB), 38043
- Sylvie Lantuejoul
- Department of Pathology, CHUGA, INSERM U 1209, University of Grenobles Alpes, Institute of Advanced Biosciences (IAB), 38043
- Nicolas Lemaitre
- Department of Pathology, CHUGA, INSERM U 1209, University of Grenobles Alpes, Institute of Advanced Biosciences (IAB), 38043
- Alex Soltermann
- Institute of Pathology and Molecular Pathology, University Hospital Zurich
- Walter Weder
- Department of Thoracic Surgery, University Hospital Zurich
- Verena Tischler
- Institute of Pathology and Molecular Pathology, University Hospital Zurich
- Odd Terje Brustugun
- Institute of Clinical Medicine, Faculty of Medicine, University of Oslo
- Marius Lund-Iversen
- Department of Pathology, Norwegian Radium Hospital, Oslo University Hospital
- Åslaug Helland
- Department of Thoracic Surgery, University Hospital Zurich
- Steinar Solberg
- Department of Thoracic Surgery, Rikshospitalet, Oslo University Hospital
- Sascha Ansén
- Department of Internal Medicine, Center of Integrated Oncology Cologne-Bonn, University Hospital Cologne
- Gavin Wright
- Department of Surgery, St. Vincent’s Hospital, Peter MacCallum Cancer Centre
- Benjamin Solomon
- Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre
- Luca Roz
- Tumor Genomics Unit, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS—Istituto Nazionale Tumori
- Ugo Pastorino
- Thoracic Surgery Unit, Department of Surgery, Fondazione IRCCS Istituto Nazionale Tumori
- Iver Petersen
- Institute of Pathology, Jena University Hospital, Friedrich-Schiller-University
- Joachim H. Clement
- Department of Internal Medicine II, Jena University Hospital, Friedrich-Schiller-University
- Jörg Sänger
- Institute for Pathology Bad Berka
- Jürgen Wolf
- Department of Internal Medicine, Center of Integrated Oncology Cologne-Bonn, University Hospital Cologne
- Martin Vingron
- Computational Molecular Biology Group, Max Planck Institute for Molecular Genetics
- Thomas Zander
- Gastrointestinal Cancer Group Cologne, Center of Integrated Oncology Cologne–Bonn, Department I for Internal Medicine, University Hospital of Cologne
- Sven Perner
- Pathology of the University Medical Center Schleswig-Holstein, Campus Luebeck and the Research Center Borstel, Leibniz Center for Medicine and Biosciences
- William D. Travis
- Department of Pathology, Memorial Sloan-Kettering Cancer Center
- Stefan A. Haas
- Computational Molecular Biology Group, Max Planck Institute for Molecular Genetics
- Magali Olivier
- Molecular Mechanisms and Biomarkers Group, Section of Mechanisms of Carcinogenesis, International Agency for Research on Cancer (IARC-WHO)
- Matthieu Foll
- Genetic Cancer Susceptibility Group, Section of Genetics, International Agency for Research on Cancer (IARC-WHO)
- Reinhard Büttner
- Department of Pathology, University Hospital Cologne
- David Neil Hayes
- UNC Lineberger Comprehensive Cancer Center School of Medicine, University of North Carolina at Chapel Hill
- Elisabeth Brambilla
- Department of Pathology, CHUGA, INSERM U 1209, University of Grenobles Alpes, Institute of Advanced Biosciences (IAB), 38043
- Lynnette Fernandez-Cuesta
- Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne
- Roman K. Thomas
- Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne
- DOI
- https://doi.org/10.1038/s41467-018-03099-x
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
The molecular nature of large-cell neuroendocrine lung carcinomas (LCNEC) has remained unclear. Here, the authors show LCNECs represent a distinct transcriptional subgroup among lung cancers and comprise two molecular subgroups, type I (TP53 and STK11/KEAP1 alterations) and type II (TP53 and RB1 inactivation).
