Frontiers in Medicine (Mar 2023)

Targeting intracellular pathways in idiopathic inflammatory myopathies: A narrative review

  • Gaetano La Rocca,
  • Francesco Ferro,
  • Chiara Baldini,
  • Alessandro Libra,
  • Domenico Sambataro,
  • Michele Colaci,
  • Lorenzo Malatino,
  • Stefano Palmucci,
  • Carlo Vancheri,
  • Gianluca Sambataro,
  • Gianluca Sambataro

DOI
https://doi.org/10.3389/fmed.2023.1158768
Journal volume & issue
Vol. 10

Abstract

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In recent decades, several pieces of evidence have drawn greater attention to the topic of innate immunity, in particular, interferon (IFN) and Interleukin 6 in the pathogenesis of idiopathic inflammatory myopathies (IIM). Both of these molecules transduce their signal through a receptor coupled with Janus kinases (JAK)/signal transducer and activator of transcription proteins (STAT). In this review, we discuss the role of the JAK/STAT pathway in IIM, evaluate a possible therapeutic role for JAK inhibitors in this group of diseases, focusing on those with the strongest IFN signature (dermatomyositis and antisynthetase syndrome).

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