Dissolution improvement of binary solid dispersions of Carbamazepine using Poly (2-ethyl-2-oxazoline) as the hydrophilic carrier

Abstract

The aim of this study was to design and evaluate the properties of solid dispersions of carbamazepine (CBZ) using poly (2-ethyl-2-oxazoline) (POX) as the hydrophilic carrier. These binary solid dispersions were prepared at varying drug loadings using the solvent evaporation method. The samples were evaluated for their in vitro dissolution, and solid-state properties. There was over 350% increase in dissolution rate of CBZ in samples containing at least 50% POX. This study concludes that POX is an effective hydrophilic carrier for poorly soluble drugs in solid dispersions.

Keywords

• poly (2-ethyl-2-oxazoline)
• solid dispersions
• dissolution
• carbamazepine
• solvent evaporation