IMMUNE DISTURBANCES AND SUBSTANTIATION OF THEIR CORRECTION IN THE CHILDREN WITH CHRONIC GASTRODUODENITIS

Abstract

Abstract. 72 patients and 30 healthy children of the age of 7-17 years were examined, aiming for substantiation of thymaline, vilon and ventramine application in treatment of chronic gastroduodenitis in children. Disbalance of cellular and humoral immunity and reduction of intensity of lymphocyte-platelet adhesions were established. An increase of IL-1β, IL-2, TNFα and IFNα concentration was registered in absence of IL-4 changes. Application of thymaline, vilon and ventramine essentially improves clinical course of disease, results in normalization of immune profile, reduced levels of proimflammatory cytokines, restoration of lymphocyte-platelet adhesions.

Keywords

• children
• gastroduodenitis
• immunity
• cytokines