ROS attenuates TET2-dependent ZO-1 epigenetic expression in cerebral vascular endothelial cells

Lan Wang; Bei Mao; Keyang Fan; Renqiang Sun; Jialong Zhang; Huazheng Liang; Ying Liu

doi:10.1186/s12987-022-00370-8

Fluids and Barriers of the CNS (Sep 2022)

ROS attenuates TET2-dependent ZO-1 epigenetic expression in cerebral vascular endothelial cells

Lan Wang,
Bei Mao,
Keyang Fan,
Renqiang Sun,
Jialong Zhang,
Huazheng Liang,
Ying Liu

Affiliations

Lan Wang: Department of Pathology, School of Basic Medical Science, Fudan University
Bei Mao: Department of Pathology, School of Basic Medical Science, Fudan University
Keyang Fan: Department of Pathology, School of Basic Medical Science, Fudan University
Renqiang Sun: Molecular and Cell Biology Lab, Institutes of Biomedical Sciences, Shanghai Medical College of Fudan University
Jialong Zhang: Department of Pathology, School of Basic Medical Science, Fudan University
Huazheng Liang: Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University
Ying Liu: Department of Pathology, School of Basic Medical Science, Fudan University

DOI: https://doi.org/10.1186/s12987-022-00370-8
Journal volume & issue: Vol. 19, no. 1
pp. 1 – 14

Abstract

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Keypoints 1. The expression of tight junction protein ZO-1 decreased significantly in the aged human brain. 2. TET activity of cerebral endothelial cells declines during aging. 3. TET activity is essential in regulating the expression of ZO-1 by endothelial cells of BBB.

Published in Fluids and Barriers of the CNS

ISSN: 2045-8118 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: https://fluidsbarrierscns.biomedcentral.com

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Abstract

Keywords