Immunity & Ageing (Nov 2018)

Healthy elderly Singaporeans show no age-related humoral hyporesponsiveness nor diminished plasmablast generation in response to influenza vaccine

  • Xavier Camous,
  • Lucian Visan,
  • Crystal Tan Tze Ying,
  • Brian Abel,
  • Ma Shwe Zin Nyunt,
  • Vipin Narang,
  • Michael Poidinger,
  • Christophe Carre,
  • Sanie Sesay,
  • Nabil Bosco,
  • Nicolas Burdin,
  • Paul Anantharajah Tambyah,
  • Ng Tze Pin,
  • Anis Larbi

DOI
https://doi.org/10.1186/s12979-018-0137-4
Journal volume & issue
Vol. 15, no. 1
pp. 1 – 6

Abstract

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Abstract Improving influenza vaccine efficacy is a priority to reduce the burden of influenza-associated morbidity and mortality. By careful selection of individuals based on health we show sustained response to influenza vaccination in older adults. Sustaining health in aging could be an important player in maintaining immune responses to influenza vaccination. Trial registration NCT03266237. Registered 30 August 2017, https://clinicaltrials.gov/ct2/show/NCT03266237.

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