Nature Communications (Feb 2021)
GWAS for autoimmune Addison’s disease identifies multiple risk loci and highlights AIRE in disease susceptibility
- Daniel Eriksson,
- Ellen Christine Røyrvik,
- Maribel Aranda-Guillén,
- Amund Holte Berger,
- Nils Landegren,
- Haydee Artaza,
- Åsa Hallgren,
- Marianne Aardal Grytaas,
- Sara Ström,
- Eirik Bratland,
- Ileana Ruxandra Botusan,
- Bergithe Eikeland Oftedal,
- Lars Breivik,
- Marc Vaudel,
- Øyvind Helgeland,
- Alberto Falorni,
- Anders Palmstrøm Jørgensen,
- Anna-Lena Hulting,
- Johan Svartberg,
- Olov Ekwall,
- Kristian Johan Fougner,
- Jeanette Wahlberg,
- Bjørn Gunnar Nedrebø,
- Per Dahlqvist,
- The Norwegian Addison Registry Study Group,
- The Swedish Addison Registry Study Group,
- Per Morten Knappskog,
- Anette Susanne Bøe Wolff,
- Sophie Bensing,
- Stefan Johansson,
- Olle Kämpe,
- Eystein Sverre Husebye
Affiliations
- Daniel Eriksson
- Centre for Molecular Medicine, Department of Medicine (Solna), Karolinska Institutet
- Ellen Christine Røyrvik
- Department of Clinical Science, University of Bergen
- Maribel Aranda-Guillén
- Centre for Molecular Medicine, Department of Medicine (Solna), Karolinska Institutet
- Amund Holte Berger
- Department of Clinical Science, University of Bergen
- Nils Landegren
- Centre for Molecular Medicine, Department of Medicine (Solna), Karolinska Institutet
- Haydee Artaza
- Department of Clinical Science, University of Bergen
- Åsa Hallgren
- Centre for Molecular Medicine, Department of Medicine (Solna), Karolinska Institutet
- Marianne Aardal Grytaas
- Department of Clinical Science, University of Bergen
- Sara Ström
- Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital
- Eirik Bratland
- Department of Clinical Science, University of Bergen
- Ileana Ruxandra Botusan
- Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital
- Bergithe Eikeland Oftedal
- Department of Clinical Science, University of Bergen
- Lars Breivik
- Department of Clinical Science, University of Bergen
- Marc Vaudel
- Center for Diabetes Research, Department of Clinical Science, University of Bergen
- Øyvind Helgeland
- Center for Diabetes Research, Department of Clinical Science, University of Bergen
- Alberto Falorni
- Department of Medicine, University of Perugia
- Anders Palmstrøm Jørgensen
- Section of Specialized Endocrinology, Department of Endocrinology, Oslo University Hospital
- Anna-Lena Hulting
- Department of Molecular Medicine and Surgery, Karolinska Institutet
- Johan Svartberg
- Tromsø Endocrine Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway
- Olov Ekwall
- Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg
- Kristian Johan Fougner
- Department of Endocrinology, St. Olavs Hospital
- Jeanette Wahlberg
- Department of Endocrinology, Linköping University
- Bjørn Gunnar Nedrebø
- Department of Clinical Science, University of Bergen
- Per Dahlqvist
- Department of Public Health and Clinical Medicine, Umeå University
- The Norwegian Addison Registry Study Group
- The Swedish Addison Registry Study Group
- Per Morten Knappskog
- Department of Clinical Science, University of Bergen
- Anette Susanne Bøe Wolff
- Department of Clinical Science, University of Bergen
- Sophie Bensing
- Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital
- Stefan Johansson
- Department of Clinical Science, University of Bergen
- Olle Kämpe
- Centre for Molecular Medicine, Department of Medicine (Solna), Karolinska Institutet
- Eystein Sverre Husebye
- Centre for Molecular Medicine, Department of Medicine (Solna), Karolinska Institutet
- DOI
- https://doi.org/10.1038/s41467-021-21015-8
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Autoimmune Addison’s disease is a rare complex disease, which has not yet been characterized by non-biased genetic studies. Here, the authors perform the first GWAS for the disease, identifying nine loci including two coding variants in the gene Autoimmune Regulator (AIRE).
