Nature Communications (Dec 2022)
A widely distributed family of eukaryotic and bacterial deubiquitinases related to herpesviral large tegument proteins
Abstract
The authors describe the VTD-deubiquitinases, a new eukaryotic enzyme family that is distantly related to herpesviral large tegument proteins. Structures of two family members with different linkage preferences allow insights into the mechanism and chain-specificity of this unusual deubiquitinase class.