BMJ Open (Jul 2023)
Prevalence, management and efficacy of treatment in portal vein obstruction after paediatric liver transplantation: protocol of the retrospective international multicentre PORTAL registry
- Barbara E Wildhaber,
- Martin de Santibañes,
- Victoria Ardiles,
- Ruben H J de Kleine,
- Raj Prasad,
- Bhargava Mullapudi,
- Jai Patel,
- Reinoud P H Bokkers,
- Ekkehard Sturm,
- Simon McGuirk,
- Girish Gupte,
- John McCall,
- Richard J Hendrickson,
- Winita Hardikar,
- Helen Evans,
- Khalid Sharif,
- Marumbo Mtegha,
- Amar Mukund,
- David Duncan,
- Emmanuel Gonzales,
- Marco Spada,
- Mureo Kasahara,
- Denise Aldrian,
- Bader A Alfares,
- Hubert P J van der Doef,
- Thomas Casswall,
- Greg Nowak,
- Martin Delle,
- Valeria Berchtold,
- Georg F Vogel,
- Piotr Kaliciński,
- Malgorzata Markiewicz-Kijewska,
- Adam Kolesnik,
- Jesús Q Bernabeu,
- María Mercadal Hally,
- Mauricio Larrarte K,
- Paolo Marra,
- Michela Bravi,
- Domenico Pinelli,
- Seisuke Sakamoto,
- Hajime Uchida,
- Vidyadhar Mali,
- Marion Aw,
- Stéphanie Franchi-Abella,
- Florent Guérin,
- Guillermo Cervio,
- Julia Minetto,
- Sergio Sierre,
- Jimmy Walker Uno,
- Steffen Hartleif,
- Cristina T Ferreira,
- Luiza S Nader,
- Marco Farina,
- Catalina Jaramillo,
- Manuel I Rodriguez-Davalos,
- Peter Feola,
- Amit A Shah,
- Phoebe M Wood,
- Michael R Acord,
- Ryan T Fischer,
- Rajeev Khanna,
- Viniyendra Pamecha,
- Gilda Porta,
- Tommaso Alterio,
- Giuseppe Maggiore,
- Marisa Beretta,
- Rudi Dierckx
Affiliations
- Barbara E Wildhaber
- Swiss Paediatric Liver Centre, Division of Child and Adolescent Surgery, Geneva University Hospitals, Geneve, Switzerland
- Martin de Santibañes
- HPB and Liver Transplant Unit, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
- Victoria Ardiles
- HPB and Liver Transplant Unit, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
- Ruben H J de Kleine
- Division of Hepatobiliary Surgery & Liver Transplantation, Department of Surgery, University Medical Centre Groningen, Groningen, The Netherlands
- Raj Prasad
- Department of Surgery and Transplantation, Leeds Teaching Hospitals NHS Trust, Leeds, UK
- Bhargava Mullapudi
- Department of Paediatric Surgery, Children`s Mercy Hospital Kansas, Overland Park, Kansas, USA
- Jai Patel
- Department of Radiology, Leeds Teaching Hospitals NHS Trust, Leeds, UK
- Reinoud P H Bokkers
- Department of Radiology, Medical Imaging Center, University Medical Centre Groningen, Groningen, The Netherlands
- Ekkehard Sturm
- Paediatric Gastroenterology and Hepatology, University Hospitals Tubingen, Tubingen, Germany
- Simon McGuirk
- Department of Interventional Radiology, Birmingham Women’s and Children’s Hospitals NHS Foundation Trust, Birmingham, UK
- Girish Gupte
- Liver Unit, Birmingham Women’s and Children’s Hospitals NHS Foundation Trust, Birmingham, UK
- John McCall
- Liver Transplant Unit, Starship Children`s Health, Auckland, New Zealand
- Richard J Hendrickson
- Department of Paediatric Surgery, Children`s Mercy Hospital Kansas, Overland Park, Kansas, USA
- Winita Hardikar
- Department of Pediatrics, Royal Children`s Hospital Research Institute, Parkville, Victoria, Australia
- Helen Evans
- Novartis Institutes for BioMedical Research Basel, Basel, Basel-Stadt, Switzerland
- Khalid Sharif
- Liver Unit, Birmingham Women’s and Children’s Hospitals NHS Foundation Trust, Birmingham, UK
- Marumbo Mtegha
- Department of Paediatrics, Leeds Teaching Hospitals NHS Trust, Leeds, UK
- Amar Mukund
- Department of Interventional Radiology, Institute of Liver and Biliary Sciences, New Delhi, Delhi, India
- David Duncan
- 39 Department of Interventional Radiology, Auckland City Hospital, Auckland, Auckland, New Zealand
- Emmanuel Gonzales
- Paediatric Hepatology and Paediatric Liver Transplantation Unit, Hôpital Bicêtre, Paris, France
- Marco Spada
- Department of Pediatrics, University of Turin, Torino, Italy
- Mureo Kasahara
- Organ Transplantation Centre, National Center for Child Health and Development, Tokyo, Japan
- Denise Aldrian
- Department of Paediatrics, Medical University of Innsbruck, Innsbruck, Austria
- Bader A Alfares
- Department of Radiology, Medical Imaging Center, University Medical Centre Groningen, Groningen, The Netherlands
- Hubert P J van der Doef
- Division of Paediatric Gastroenterology and Hepatology, Department of Paediatrics, University Medical Centre Groningen, Groningen, The Netherlands
- Thomas Casswall
- Department Clinical Interventions and Technology Clintec, Division for Paediatrics, Karolinska Institute, Stockholm, Sweden
- Greg Nowak
- Department Clinical Interventions and Technology Clintec, Division for Transplantation Surgery, Karolinska Institute, Stockholm, Sweden
- Martin Delle
- Department Clinical Science, Intervention and Technology Clintec, Division for Interventional Radiology, Karolinska Institute, Stockholm, Sweden
- Valeria Berchtold
- Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, Innsbruck, Austria
- Georg F Vogel
- Institute of Cell Biology, Medical University of Innsbruck, Innsbruck, Austria
- Piotr Kaliciński
- Department of Paediatric Surgery and Organ Transplantation, The Children’s Memorial Health Institute, Warsaw, Poland
- Malgorzata Markiewicz-Kijewska
- Department of Paediatric Surgery and Organ Transplantation, The Children’s Memorial Health Institute, Warsaw, Poland
- Adam Kolesnik
- Cardiovascular Interventions Laboratory, The Children’s Memorial Health Institute, Warsaw, Poland
- Jesús Q Bernabeu
- Department of Paediatric Gastroenterology, Hepatology and Nutrition, Vall d’Hebron Hospital (HVH), Barcelona, Spain
- María Mercadal Hally
- Department of Paediatric Gastroenterology, Hepatology and Nutrition, Vall d’Hebron Hospital (HVH), Barcelona, Spain
- Mauricio Larrarte K
- Department of Paediatric Gastroenterology, Hepatology and Nutrition, Vall d’Hebron Hospital (HVH), Barcelona, Spain
- Paolo Marra
- Department of Radiology, ASST Papa Giovanni XXIII, Bergamo, Italy
- Michela Bravi
- Department of Paediatric Hepatology, Gastroenterology and Transplantation, ASST Papa Giovanni XXIII, Bergamo, Italy
- Domenico Pinelli
- Department of Organ Failure and Transplantation, ASST Papa Giovanni XXIII, Bergamo, Italy
- Seisuke Sakamoto
- Organ Transplantation Centre, National Center for Child Health and Development, Tokyo, Japan
- Hajime Uchida
- Organ Transplantation Centre, National Center for Child Health and Development, Tokyo, Japan
- Vidyadhar Mali
- Department of Paediatric Surgery, National University Hospital, Singapore
- Marion Aw
- Department of Paediatrics, National University Hospital, Singapore
- Stéphanie Franchi-Abella
- Department of Paediatric Radiology, Hôpital Bicêtre, Paris, France
- Florent Guérin
- Paediatric Surgery and Paediatric Liver Transplantation Unit, Hôpital Bicêtre, Paris, France
- Guillermo Cervio
- Division of Liver Transplant, Hospital de Pediatría Prof Dr Juan P Garrahan, Buenos Aires, Argentina
- Julia Minetto
- Division of Liver Transplant, Hospital de Pediatría Prof Dr Juan P Garrahan, Buenos Aires, Argentina
- Sergio Sierre
- Division of Interventional Radiology, Hospital de Pediatría Prof Dr Juan P Garrahan, Buenos Aires, Argentina
- Jimmy Walker Uno
- HPB and Liver Transplant Unit, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
- Steffen Hartleif
- Paediatric Gastroenterology and Hepatology, University Hospitals Tubingen, Tubingen, Germany
- Cristina T Ferreira
- Department of Paediatrics, Hospital Santo Antonio, Porto Alegre, Brazil
- Luiza S Nader
- Department of Paediatrics, Hospital Santo Antonio, Porto Alegre, Brazil
- Marco Farina
- Department of Paediatrics, Hospital Santo Antonio, Porto Alegre, Brazil
- Catalina Jaramillo
- Department of Paediatrics, Division of Paediatric Gastroenterology, Hepatology and Nutrition, The University of Utah School of Medicine, Salt Lake City, Utah, USA
- Manuel I Rodriguez-Davalos
- Department of Surgery, The University of Utah School of Medicine, Salt Lake City, Utah, USA
- Peter Feola
- Paediatric Interventional Radiology, The University of Utah School of Medicine, Salt Lake City, Utah, USA
- Amit A Shah
- Division of Gastroenterology, Hepatology and Nutrition, Department of Paediatrics, The Children`s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
- Phoebe M Wood
- Division of Gastroenterology, Hepatology and Nutrition, Department of Paediatrics, The Children`s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
- Michael R Acord
- Department of Radiology, The Children`s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
- Ryan T Fischer
- Division of Paediatric Gastroenterology and Hepatology, Department of Paediatrics, Children`s Mercy Hospital Kansas, Overland Park, Kansas, USA
- Rajeev Khanna
- Department of Paediatric Hepatology, Institute of Liver and Biliary Sciences, New Delhi, Delhi, India
- Viniyendra Pamecha
- 2 Hepatopancreaticobiliary Surgery and Liver Transplantation, Institute of Liver and Biliary Sciences, Delhi, India
- Gilda Porta
- Department of Paediatric Hepatology, Hospital Sírio-Libanês, Sao Paulo, Brazil
- Tommaso Alterio
- Gastrointestinal, Liver, Nutrition Disorders Unit, IRCCS Pediatric Hospital Bambino Gesù, Rome, Italy
- Giuseppe Maggiore
- Gastrointestinal, Liver, Nutrition Disorders Unit, IRCCS Pediatric Hospital Bambino Gesù, Rome, Italy
- Marisa Beretta
- Faculty of Health Sciences, Wits Donald Gordon Medical Centre, Johannesburg, South Africa
- Rudi Dierckx
- Department of Radiology, Medical Imaging Center, University Medical Centre Groningen, Groningen, The Netherlands
- DOI
- https://doi.org/10.1136/bmjopen-2022-066343
- Journal volume & issue
-
Vol. 13,
no. 7
Abstract
Introduction Portal vein obstruction (PVO) consists of anastomotic stenosis and thrombosis, which occurs due to a progression of the former. The aim of this large-scale international study is to assess the prevalence, current management practices and efficacy of treatment in patients with PVO.Methods and analysis The Portal vein Obstruction Revascularisation Therapy After Liver transplantation registry will facilitate an international, retrospective, multicentre, observational study, with 25 centres around the world already actively involved. Paediatric patients (aged <18 years) with a diagnosed PVO between 1 January 2001 and 1 January 2021 after liver transplantation will be eligible for inclusion. The primary endpoints are the prevalence of PVO, primary and secondary patency after PVO intervention and current management practices. Secondary endpoints are patient and graft survival, severe complications of PVO and technical success of revascularisation techniques.Ethics and dissemination Medical Ethics Review Board of the University Medical Center Groningen has approved the study (METc 2021/072). The results of this study will be disseminated via peer-reviewed publications and scientific presentations at national and international conferences.Trial registration number Netherlands Trial Register (NL9261).
