Nature Communications (Nov 2018)
Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma
- Weitao Lin,
- Yim Ling Yip,
- Lin Jia,
- Wen Deng,
- Hong Zheng,
- Wei Dai,
- Josephine Mun Yee Ko,
- Kwok Wai Lo,
- Grace Tin Yun Chung,
- Kevin Y. Yip,
- Sau-Dan Lee,
- Johnny Sheung-Him Kwan,
- Jun Zhang,
- Tengfei Liu,
- Jimmy Yu-Wai Chan,
- Dora Lai-Wan Kwong,
- Victor Ho-Fun Lee,
- John Malcolm Nicholls,
- Pierre Busson,
- Xuefeng Liu,
- Alan Kwok Shing Chiang,
- Kwai Fung Hui,
- Hin Kwok,
- Siu Tim Cheung,
- Yuk Chun Cheung,
- Chi Keung Chan,
- Bin Li,
- Annie Lai-Man Cheung,
- Pok Man Hau,
- Yuan Zhou,
- Chi Man Tsang,
- Jaap Middeldorp,
- Honglin Chen,
- Maria Li Lung,
- Sai Wah Tsao
Affiliations
- Weitao Lin
- School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Yim Ling Yip
- School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Lin Jia
- School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Wen Deng
- School of Nursing, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Hong Zheng
- Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Wei Dai
- Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Josephine Mun Yee Ko
- Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Kwok Wai Lo
- Department of Anatomical and Cellular Pathology and State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong
- Grace Tin Yun Chung
- Department of Anatomical and Cellular Pathology and State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong
- Kevin Y. Yip
- Department of Computer Science and Engineering, The Chinese University of Hong Kong
- Sau-Dan Lee
- Department of Computer Science and Engineering, The Chinese University of Hong Kong
- Johnny Sheung-Him Kwan
- Department of Anatomical and Cellular Pathology and State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong
- Jun Zhang
- School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Tengfei Liu
- School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Jimmy Yu-Wai Chan
- Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Dora Lai-Wan Kwong
- Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Victor Ho-Fun Lee
- Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- John Malcolm Nicholls
- Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Pierre Busson
- Gustave Roussy, Paris-Saclay University, CNRS
- Xuefeng Liu
- Center for Cell Reprogramming, Department of Pathology, Georgetown University Medical Center
- Alan Kwok Shing Chiang
- Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Kwai Fung Hui
- Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Hin Kwok
- Center for Genomic Sciences, The University of Hong Kong
- Siu Tim Cheung
- Department of Surgery and Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong
- Yuk Chun Cheung
- School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Chi Keung Chan
- School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Bin Li
- School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Annie Lai-Man Cheung
- School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Pok Man Hau
- Department of Anatomical and Cellular Pathology and State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong
- Yuan Zhou
- Department of Anatomical and Cellular Pathology and State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong
- Chi Man Tsang
- School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Jaap Middeldorp
- VU University Medical Center, Department of Pathology, Cancer Center Amsterdam
- Honglin Chen
- Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Maria Li Lung
- Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Sai Wah Tsao
- School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- DOI
- https://doi.org/10.1038/s41467-018-06889-5
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 17
Abstract
The lack of appropriate models restricts pre-clinical research for nasopharyngeal carcinoma (NPC). Here the authors report the development and characterization of NPC patient-derived xenografts (PDXs), and EBV positive NPC cell line from patient tumor, and suggest their potential use in future NPC research.
