Glutamic acid is a carrier for hydrazine during the biosyntheses of fosfazinomycin and kinamycin

Kwo-Kwang A. Wang; Tai L. Ng; Peng Wang; Zedu Huang; Emily P. Balskus; Wilfred A. van der Donk

doi:10.1038/s41467-018-06083-7

Nature Communications (Sep 2018)

Glutamic acid is a carrier for hydrazine during the biosyntheses of fosfazinomycin and kinamycin

Kwo-Kwang A. Wang,
Tai L. Ng,
Peng Wang,
Zedu Huang,
Emily P. Balskus,
Wilfred A. van der Donk

Affiliations

Kwo-Kwang A. Wang: Department of Chemistry, University of Illinois at Urbana-Champaign
Tai L. Ng: Department of Chemistry and Chemical Biology, Harvard University
Peng Wang: Department of Chemistry and Chemical Biology, Harvard University
Zedu Huang: Department of Chemistry, University of Illinois at Urbana-Champaign
Emily P. Balskus: Department of Chemistry and Chemical Biology, Harvard University
Wilfred A. van der Donk: Department of Chemistry, University of Illinois at Urbana-Champaign

DOI: https://doi.org/10.1038/s41467-018-06083-7
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

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The natural products fosfazinomycin A and kinamycin D are structurally distinct except for a nitrogen-nitrogen (N-N) bond. Here, the authors show that fosfazinomycin and kinamycin share a common pathway for N-N bond formation that is different from pathways found for other natural products.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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