Nature Communications (Mar 2022)
The flavonoid corylin exhibits lifespan extension properties in mouse
- Tong-Hong Wang,
- Wei-Che Tseng,
- Yann-Lii Leu,
- Chi-Yuan Chen,
- Wen-Chih Lee,
- Ying-Chih Chi,
- Shu-Fang Cheng,
- Chun-Yu Lai,
- Chen-Hsin Kuo,
- Shu-Ling Yang,
- Sien-Hung Yang,
- Jiann-Jong Shen,
- Chun-Hao Feng,
- Chih-Ching Wu,
- Tsong-Long Hwang,
- Chia-Jen Wang,
- Shu-Huei Wang,
- Chin-Chuan Chen
Affiliations
- Tong-Hong Wang
- Tissue Bank, Chang Gung Memorial Hospital
- Wei-Che Tseng
- Graduate Institute of Natural Products, Chang Gung University
- Yann-Lii Leu
- Tissue Bank, Chang Gung Memorial Hospital
- Chi-Yuan Chen
- Tissue Bank, Chang Gung Memorial Hospital
- Wen-Chih Lee
- Office of Research and Development, Tzu Chi University
- Ying-Chih Chi
- Cryo-EM Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center
- Shu-Fang Cheng
- Graduate Institute of Natural Products, Chang Gung University
- Chun-Yu Lai
- Graduate Institute of Natural Products, Chang Gung University
- Chen-Hsin Kuo
- Graduate Institute of Natural Products, Chang Gung University
- Shu-Ling Yang
- School of Traditional Chinese Medicine, Chang Gung University
- Sien-Hung Yang
- School of Traditional Chinese Medicine, Chang Gung University
- Jiann-Jong Shen
- School of Traditional Chinese Medicine, Chang Gung University
- Chun-Hao Feng
- Graduate Institute of Natural Products, Chang Gung University
- Chih-Ching Wu
- Department of Medical Biotechnology and Laboratory Science, Chang Gung University
- Tsong-Long Hwang
- Graduate Institute of Health Industry Technology, Research Center for Food and Cosmetic Safety, Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology
- Chia-Jen Wang
- Cell Therapy Core Laboratory, Chang Gung Memorial Hospital
- Shu-Huei Wang
- Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University
- Chin-Chuan Chen
- Tissue Bank, Chang Gung Memorial Hospital
- DOI
- https://doi.org/10.1038/s41467-022-28908-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
Various traditional Chinese herbs and complex formulas have been suggested to exhibit lifespan extension properties. Here, the authors isolated the flavonoid corylin from Psoralea corylifolia and demonstrated its longevity properties in yeast, human cells and mouse.
