Drug-Induced Liver Injury in Tuberculosis: Mechanisms of Development and Diagnostic Methods

Abstract

The review article discusses modern aspects of drug-induced liver injury (DILI) in patients with tuberculosis who are receiving etiotropic therapy. The main mechanisms of DILI, including toxic and idiosyncratic types, are described, as well as their pathogenetic, biochemical, and epidemiological differences. DILI can manifest as various clinicomorphological forms of liver damage, such as steatosis and steatohepatitis, acute and chronic hepatitis, mitochondrial cytopathy, cholestasis, sclerosing cholangitis, vascular injury, and others. The main diagnostic method for DILI is the detection of liver enzymes — transaminases and alkaline phosphatase — based on the degree of elevation and their ratio, which identify two main types of liver injury — hepatocellular and cholestatic — as well as a mixed variant. The article provides a scoring assessment of liver damage in a patient receiving chemotherapy to classify it as drug-induced liver injury.

Keywords

• drug-induced liver injury
• drug hepatitis
• toxic hepatitis
• tuberculosis
• diagnostic criteria
• transaminases
• etiotropic therapy
• liver enzymes
• diagnosis