Regularities in disturbances of cytological composition of synovial fluid and activity of free radical oxidative processes in case of experimental joint injury and possibility of their pathogenetic correction

Abstract

The purpose of the study was to study the influence of complex peroral nimesulid administration and intraarticular etoxidol injection on lipid peroxidation processes and activity of the endogenic antioxidant system on cytological composition of synovial fluid in experimental post-traumatic arthritis.Materials and methods. The experiments were carried out on 108 white nonlinear rats of both sexes and with a body weight of 180–200 g. The animals were divided into 4 series and excluded from the experiment on the 28th day.Conclusion. It was established that peroral catheter nimesulid injection in combination with intra-articular etoxidol injection has a significant impact on lipid peroxidation processes, on activity of the endogenic antioxidant system and on cytological composition of synovial fluid.

Keywords

• посттравматический артрит
• перекисное окисление липидов
• синовиальная жидкость
• нимесулид
• этоксидол