A facile microwave assisted one-pot synthesis of novel 1-methylhexahydroquinazolin-5(6H)-ones and bis-1-methylhexahydroquinazolin-5(6H)-ones

Abstract

Novel hexahydroquinazolin-5(6H)-ones 3a-j have been synthesized in good yields by the reaction of enaminones 2a-b with primary amines and formaldehyde under the influence microwaves. Enaminones 2a-b have also been reacted with diamines and formaldehyde under similar conditions resulting in hitherto unreported bis- hexahydroquinazolin-5(6H)-ones 4a-d and 5a-d. The structures of the molecules have been established with the help of spectral and analytical data.

Keywords

• hexahydroquinazolin-5(6h)-ones
• bis-hexahydroquinazolin-5(6h)-ones
• dimedone
• enaminone
• 1,3-cyclohexanedione