Nature Communications (May 2022)
Versican promotes T helper 17 cytotoxic inflammation and impedes oligodendrocyte precursor cell remyelination
- Samira Ghorbani,
- Emily Jelinek,
- Rajiv Jain,
- Benjamin Buehner,
- Cenxiao Li,
- Brian M. Lozinski,
- Susobhan Sarkar,
- Deepak K. Kaushik,
- Yifei Dong,
- Thomas N. Wight,
- Soheila Karimi-Abdolrezaee,
- Geert J. Schenk,
- Eva M. Strijbis,
- Jeroen Geurts,
- Ping Zhang,
- Chang-Chun Ling,
- V. Wee Yong
Affiliations
- Samira Ghorbani
- Hotchkiss Brain Institute and Department of Clinical Neurosciences, University of Calgary
- Emily Jelinek
- Hotchkiss Brain Institute and Department of Clinical Neurosciences, University of Calgary
- Rajiv Jain
- Hotchkiss Brain Institute and Department of Clinical Neurosciences, University of Calgary
- Benjamin Buehner
- Hotchkiss Brain Institute and Department of Clinical Neurosciences, University of Calgary
- Cenxiao Li
- Hotchkiss Brain Institute and Department of Clinical Neurosciences, University of Calgary
- Brian M. Lozinski
- Hotchkiss Brain Institute and Department of Clinical Neurosciences, University of Calgary
- Susobhan Sarkar
- Hotchkiss Brain Institute and Department of Clinical Neurosciences, University of Calgary
- Deepak K. Kaushik
- Hotchkiss Brain Institute and Department of Clinical Neurosciences, University of Calgary
- Yifei Dong
- Hotchkiss Brain Institute and Department of Clinical Neurosciences, University of Calgary
- Thomas N. Wight
- Benaroya Research Institute
- Soheila Karimi-Abdolrezaee
- Department of Physiology and Pathophysiology, University of Manitoba
- Geert J. Schenk
- Department of Anatomy and Neurosciences, Amsterdam Neuroscience, MS Center Amsterdam
- Eva M. Strijbis
- Neurology, Amsterdam Neuroscience, MS Center Amsterdam
- Jeroen Geurts
- Department of Anatomy and Neurosciences, Amsterdam Neuroscience, MS Center Amsterdam
- Ping Zhang
- Department of Chemistry, University of Calgary
- Chang-Chun Ling
- Department of Chemistry, University of Calgary
- V. Wee Yong
- Hotchkiss Brain Institute and Department of Clinical Neurosciences, University of Calgary
- DOI
- https://doi.org/10.1038/s41467-022-30032-0
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Ghorbani and colleagues describe versican-V1 as an inhibitor of remyelination using transgenic mice that illuminate new GFP + oligodendrocytes. Mechanisms of versican-V1 include the direct inhibition of oligodendrocytes, and elevating Th17 cells.
