Nature Communications (Mar 2017)
Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene
- Marcus Lefebure,
- Richard W. Tothill,
- Elizabeth Kruse,
- Edwin D. Hawkins,
- Jake Shortt,
- Geoffrey M. Matthews,
- Gareth P. Gregory,
- Benjamin P. Martin,
- Madison J. Kelly,
- Izabela Todorovski,
- Maria A. Doyle,
- Richard Lupat,
- Jason Li,
- Jan Schroeder,
- Meaghan Wall,
- Stuart Craig,
- Gretchen Poortinga,
- Don Cameron,
- Megan Bywater,
- Lev Kats,
- Micah D. Gearhart,
- Vivian J. Bardwell,
- Ross A. Dickins,
- Ross D. Hannan,
- Anthony T. Papenfuss,
- Ricky W. Johnstone
Affiliations
- Marcus Lefebure
- The Peter MacCallum Cancer Centre
- Richard W. Tothill
- The Peter MacCallum Cancer Centre
- Elizabeth Kruse
- The Peter MacCallum Cancer Centre
- Edwin D. Hawkins
- The Walter Eliza Hall Institute of Medical Research
- Jake Shortt
- The Peter MacCallum Cancer Centre
- Geoffrey M. Matthews
- Dana Farber Cancer Institute
- Gareth P. Gregory
- The Peter MacCallum Cancer Centre
- Benjamin P. Martin
- The Peter MacCallum Cancer Centre
- Madison J. Kelly
- The Peter MacCallum Cancer Centre
- Izabela Todorovski
- The Peter MacCallum Cancer Centre
- Maria A. Doyle
- The Peter MacCallum Cancer Centre
- Richard Lupat
- The Peter MacCallum Cancer Centre
- Jason Li
- The Peter MacCallum Cancer Centre
- Jan Schroeder
- The Walter Eliza Hall Institute of Medical Research
- Meaghan Wall
- Victorian Cancer Cytogenetics Service, St Vincent’s Hospital
- Stuart Craig
- The Peter MacCallum Cancer Centre
- Gretchen Poortinga
- The Peter MacCallum Cancer Centre
- Don Cameron
- The Peter MacCallum Cancer Centre
- Megan Bywater
- The Peter MacCallum Cancer Centre
- Lev Kats
- The Peter MacCallum Cancer Centre
- Micah D. Gearhart
- and Department of Genetics, Developmental Biology Center, Masonic Cancer Center, Cell Biology, and Development, University of Minnesota
- Vivian J. Bardwell
- and Department of Genetics, Developmental Biology Center, Masonic Cancer Center, Cell Biology, and Development, University of Minnesota
- Ross A. Dickins
- Australian Centre for Blood Diseases, Monash University
- Ross D. Hannan
- The Peter MacCallum Cancer Centre
- Anthony T. Papenfuss
- The Peter MacCallum Cancer Centre
- Ricky W. Johnstone
- The Peter MacCallum Cancer Centre
- DOI
- https://doi.org/10.1038/ncomms14581
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 10
Abstract
The Eμ-Myc lymphoma mouse model has been invaluable in the study of this disease. Here, the authors use multiple sequencing strategies to analyse the tumours in these mice and find recurrent inactivating mutations in Bcor, suggesting that this gene has a negative role in Mycsignalling.
