Nature Communications (Nov 2021)
Deciphering cell lineage specification of human lung adenocarcinoma with single-cell RNA sequencing
- Zhoufeng Wang,
- Zhe Li,
- Kun Zhou,
- Chengdi Wang,
- Lili Jiang,
- Li Zhang,
- Ying Yang,
- Wenxin Luo,
- Wenliang Qiao,
- Gang Wang,
- Yinyun Ni,
- Shuiping Dai,
- Tingting Guo,
- Guiyi Ji,
- Minjie Xu,
- Yiying Liu,
- Zhixi Su,
- Guowei Che,
- Weimin Li
Affiliations
- Zhoufeng Wang
- Department of Respiratory and Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University
- Zhe Li
- Singlera Genomics Ltd
- Kun Zhou
- Department of Thoracic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou
- Chengdi Wang
- Department of Respiratory and Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University
- Lili Jiang
- Department of Pathology, West China Hospital of Sichuan University
- Li Zhang
- Department of Respiratory and Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University
- Ying Yang
- Department of Respiratory and Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University
- Wenxin Luo
- Department of Respiratory and Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University
- Wenliang Qiao
- Lung Cancer Center, West China Hospital Sichuan University
- Gang Wang
- Precision Medicine Research Center, West China Hospital, Sichuan University
- Yinyun Ni
- Department of Respiratory and Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University
- Shuiping Dai
- Center of Gerontology and Geriatrics, West China Hospital, Sichuan University
- Tingting Guo
- Department of Respiratory and Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University
- Guiyi Ji
- Health Management Center, West China Hospital, Sichuan University
- Minjie Xu
- Singlera Genomics Ltd
- Yiying Liu
- Singlera Genomics Ltd
- Zhixi Su
- Singlera Genomics Ltd
- Guowei Che
- Department of Thoracic Surgery, West China Hospital, Sichuan University
- Weimin Li
- Department of Respiratory and Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University
- DOI
- https://doi.org/10.1038/s41467-021-26770-2
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
The origin and progression of lung adenocarcinoma (LUAD) are still poorly understood. Here, the authors analyse LUAD composition and progression in patient samples using single-cell RNA-seq and multiplex imaging, revealing a potential transcriptional divergence from alveolar type 2 cells.
