International Journal of COPD (Oct 2020)
Total Antioxidant Status in Stable Chronic Obstructive Pulmonary Disease
Abstract
Marina Hlavati,1,2 Svetlana Tomić,2 Krunoslav Buljan,2 Vikica Buljanović,3 Ivan Feldi,4 Silva Butković-Soldo2 1Department of Diagnostic and Therapeutical Procedures, General Hospital Našice, Našice 31500, Croatia; 2Faculty of Medicine Osijek, University Josip Juraj Strossmayer Osijek, Osijek 31000, Croatia; 3Department for Biochemical Analysis, General Hospital Našice, Našice 31500, Croatia; 4Department of Internal Medicine, General Hospital Našice, Našice 31500, CroatiaCorrespondence: Marina Hlavati Department of Diagnostic and Therapeutical ProceduresGeneral Hospital Našice, Bana Jelačića 10, Našice 31500, CroatiaTel +385915810485Fax +38531613826Email [email protected]: This study evaluates the total antioxidant status (TAS) in plasma of stable chronic obstructive pulmonary disease (COPD) patients. Earlier studies of their relationship showed inconsistent findings.Patients and Methods: We compared TAS between 90 COPD patients and 30 age- and sex-matched controls (mean age 67 ± 7.9, 87 males and 33 females) according to airway obstruction severity, gender, smoking status (current/ former/ non-smoker), smoking-dose, the number of exacerbations in the previous year, nutritional status and hypercapnia.Results: There were no differences in pack-years between COPD and controls, neither in COPD groups. The median time from the last exacerbation was 5 months (interquartile range 3− 8.3). TAS was significant higher in COPD than controls (1.68 [1.55− 1.80] versus 1.59 [1.54− 1.68], respectively; P = 0.03). TAS was significantly higher in COPD men than women (1.7 [1.6− 1.8] versus 1.57 [1.5− 1.7], respectively; P = 0.001). In COPD groups, there were no significant differences between the severity of airway obstruction and TAS. We found significant positive correlation between pack-years and TAS in all participants (Rho = 0.429, P = 0.004) and COPD patients (Rho = 0.359, P = 0.02), but not in controls. TAS was a significant predictor of COPD (β = 3.26; P = 0.04; OR = 26.01; 95% CI: 1.20 to 570.8). We failed to find significant differences between TAS and smoking status, frequency of exacerbations in the previous year, nutritional status and hypercapnia.Conclusion: TAS was a significant predictor of COPD. TAS was a significantly higher in stable COPD than controls, higher in COPD men than women, but there was no significant correlation between TAS and the airway obstruction severity. Our results suggest that it could be appropriate to include the time from the last exacerbation in the oxidant–antioxidant balance analysis of COPD patients.Keywords: chronic obstructive pulmonary disease, antioxidants, airway obstruction severity, exacerbation, smoking
