Frontiers in Behavioral Neuroscience (Jul 2022)
Toward Precision Medicine in ADHD
- Jan Buitelaar,
- Jan Buitelaar,
- Sven Bölte,
- Sven Bölte,
- Sven Bölte,
- Daniel Brandeis,
- Daniel Brandeis,
- Arthur Caye,
- Arthur Caye,
- Nina Christmann,
- Samuele Cortese,
- Samuele Cortese,
- Samuele Cortese,
- Samuele Cortese,
- Samuele Cortese,
- David Coghill,
- Stephen V. Faraone,
- Barbara Franke,
- Markus Gleitz,
- Corina U. Greven,
- Corina U. Greven,
- Corina U. Greven,
- Sandra Kooij,
- Sandra Kooij,
- Douglas Teixeira Leffa,
- Douglas Teixeira Leffa,
- Nanda Rommelse,
- Nanda Rommelse,
- Jeffrey H. Newcorn,
- Guilherme V. Polanczyk,
- Luis Augusto Rohde,
- Luis Augusto Rohde,
- Emily Simonoff,
- Mark Stein,
- Benedetto Vitiello,
- Benedetto Vitiello,
- Yanki Yazgan,
- Yanki Yazgan,
- Michael Roesler,
- Manfred Doepfner,
- Manfred Doepfner,
- Tobias Banaschewski
Affiliations
- Jan Buitelaar
- Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, Netherlands
- Jan Buitelaar
- Karakter Child and Adolescent Psychiatry University Center, Nijmegen, Netherlands
- Sven Bölte
- Center of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research, Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden
- Sven Bölte
- Child and Adolescent Psychiatry, Stockholm Health Care Services, Stockholm, Sweden
- Sven Bölte
- Curtin Autism Research Group, School of Occupational Therapy, Social Work and Speech Pathology, Curtin University, Perth, WA, Australia
- Daniel Brandeis
- Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany
- Daniel Brandeis
- Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, Zurich, Switzerland
- Arthur Caye
- Department of Psychiatry, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
- Arthur Caye
- National Institute of Developmental Psychiatry for Children and Adolescents, São Paulo, Brazil
- Nina Christmann
- Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany
- Samuele Cortese
- 0Centre for Innovation in Mental Health, Academic Unit of Psychology, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, United Kingdom
- Samuele Cortese
- 1Clinical and Experimental Sciences (CNS and Psychiatry), Faculty of Medicine, University of Southampton, Southampton, United Kingdom
- Samuele Cortese
- 2Solent National Health System Trust, Southampton, United Kingdom
- Samuele Cortese
- 3Hassenfeld Children's Hospital at NYU Langone, New York University Child Study Center, New York, NY, United States
- Samuele Cortese
- 4Division of Psychiatry and Applied Psychology, School of Medicine, University of Nottingham, Nottingham, United Kingdom
- David Coghill
- 5Departments of Paediatrics and Psychiatry, Royal Children's Hospital, University of Melbourne, Melbourne, VIC, Australia
- Stephen V. Faraone
- 6Departments of Psychiatry, Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, New York, NY, United States
- Barbara Franke
- 7Departments of Human Genetics and Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, Netherlands
- Markus Gleitz
- 8Medice Arzneimittel Pütter GmbH & Co. KG, Iserlohn, Germany
- Corina U. Greven
- Karakter Child and Adolescent Psychiatry University Center, Nijmegen, Netherlands
- Corina U. Greven
- 9Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, Netherlands
- Corina U. Greven
- 0King's College London, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, London, United Kingdom
- Sandra Kooij
- 1Amsterdam University Medical Center, Location VUMc, Amsterdam, Netherlands
- Sandra Kooij
- 2PsyQ, Expertise Center Adult ADHD, The Hague, Netherlands
- Douglas Teixeira Leffa
- Department of Psychiatry, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
- Douglas Teixeira Leffa
- National Institute of Developmental Psychiatry for Children and Adolescents, São Paulo, Brazil
- Nanda Rommelse
- Karakter Child and Adolescent Psychiatry University Center, Nijmegen, Netherlands
- Nanda Rommelse
- 3Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, Netherlands
- Jeffrey H. Newcorn
- 4Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Guilherme V. Polanczyk
- 5Department of Psychiatry, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil
- Luis Augusto Rohde
- National Institute of Developmental Psychiatry for Children and Adolescents, São Paulo, Brazil
- Luis Augusto Rohde
- 6ADHD Outpatient Program and Developmental Psychiatry Program, Hospital de Clinica de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
- Emily Simonoff
- 7Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, United Kingdom
- Mark Stein
- 8Department of Psychiatry and Behavioral Sciences, Seattle, WA, United States
- Benedetto Vitiello
- 9Department of Public Health and Pediatric Sciences, Section of Child and Adolescent Neuropsychiatry, University of Turin, Turin, Italy
- Benedetto Vitiello
- 0Department of Public Health, Johns Hopkins University, Baltimore, MA, United States
- Yanki Yazgan
- 1GuzelGunler Clinic, Istanbul, Turkey
- Yanki Yazgan
- 2Yale Child Study Center, New Haven, CT, United States
- Michael Roesler
- 3Institute for Forensic Psychology and Psychiatry, Neurocenter, Saarland, Germany
- Manfred Doepfner
- 4Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Medical Faculty of the University of Cologne, Cologne, Germany
- Manfred Doepfner
- 5School for Child and Adolescent Cognitive Behavioural Therapy, University Hospital of Cologne, Cologne, Germany
- Tobias Banaschewski
- Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany
- DOI
- https://doi.org/10.3389/fnbeh.2022.900981
- Journal volume & issue
-
Vol. 16
Abstract
Attention-Deficit Hyperactivity Disorder (ADHD) is a complex and heterogeneous neurodevelopmental condition for which curative treatments are lacking. Whilst pharmacological treatments are generally effective and safe, there is considerable inter-individual variability among patients regarding treatment response, required dose, and tolerability. Many of the non-pharmacological treatments, which are preferred to drug-treatment by some patients, either lack efficacy for core symptoms or are associated with small effect sizes. No evidence-based decision tools are currently available to allocate pharmacological or psychosocial treatments based on the patient's clinical, environmental, cognitive, genetic, or biological characteristics. We systematically reviewed potential biomarkers that may help in diagnosing ADHD and/or stratifying ADHD into more homogeneous subgroups and/or predict clinical course, treatment response, and long-term outcome across the lifespan. Most work involved exploratory studies with cognitive, actigraphic and EEG diagnostic markers to predict ADHD, along with relatively few studies exploring markers to subtype ADHD and predict response to treatment. There is a critical need for multisite prospective carefully designed experimentally controlled or observational studies to identify biomarkers that index inter-individual variability and/or predict treatment response.
Keywords
- Attention-Deficit Hyperactivity Disorder (ADHD)
- precision medicine
- biomarker
- heterogeneity
- inter-individual variability
