Journal of Clinical Medicine (May 2020)
Management and Survival of Elderly and Very Elderly Patients with Ovarian Cancer: An Age-Stratified Study of 1123 Women from the FRANCOGYN Group
- Yolaine Joueidi,
- Ludivine Dion,
- Sofiane Bendifallah,
- Camille Mimoun,
- Alexandre Bricou,
- Krystel Nyangoh Timoh,
- Pierre Collinet,
- Cyril Touboul,
- Lobna Ouldamer,
- Henri Azaïs,
- Yohann Dabi,
- Cherif Akladios,
- Geoffroy Canlorbe,
- Pierre-Adrien Bolze,
- Hélène Costaz,
- Mathieu Mezzadri,
- Tristan Gauthier,
- Frederic Kridelka,
- Pauline Chauvet,
- Nicolas Bourdel,
- Martin Koskas,
- Xavier Carcopino,
- Emilie Raimond,
- Olivier Graesslin,
- Lise Lecointre,
- Marcos Ballester,
- Cyrille Huchon,
- Jean Levêque,
- Vincent Lavoué
Affiliations
- Yolaine Joueidi
- Department of Gynecology, Rennes University Hospital, Hôpital Sud, 35000 Rennes, France
- Ludivine Dion
- Department of Gynecology, Rennes University Hospital, Hôpital Sud, 35000 Rennes, France
- Sofiane Bendifallah
- Service de Gynécologie, Hopital TENON, AP-HP, 75020 Paris, France
- Camille Mimoun
- Department of Gynecology and Obstetrics, Lariboisiere Hospital, 75010 Paris, France
- Alexandre Bricou
- Croix Saint Simon, Service de Chirurgie Gynécologique, 75000 Paris, France
- Krystel Nyangoh Timoh
- Department of Gynecology, Rennes University Hospital, Hôpital Sud, 35000 Rennes, France
- Pierre Collinet
- Service de Gynécologie, Hôpital Jeanne de Flandres, 59000 Lille, France
- Cyril Touboul
- Service de Gynécologie, Hopital TENON, AP-HP, 75020 Paris, France
- Lobna Ouldamer
- Service de Gynécologie, CHU Tours, 37000 Tours, France
- Henri Azaïs
- Assistance Publique des Hôpitaux de Paris (AP-HP), Department of Gynecological and Breast Surgery and Oncology, Pitié-Salpêtrière University Hospital, 75013 Paris, France
- Yohann Dabi
- Service de Gynécologie Obstétrique, Centre Hospitalier Inter Communal de Créteil, 94000 Créteil, France
- Cherif Akladios
- Service de Gynécologie Obstétrique, CHU Hautepierre, 67000 Strasbourg, France
- Geoffroy Canlorbe
- Assistance Publique des Hôpitaux de Paris (AP-HP), Department of Gynecological and Breast Surgery and Oncology, Pitié-Salpêtrière University Hospital, 75013 Paris, France
- Pierre-Adrien Bolze
- Service de Gynécologie Obstétrique, CHU Lyon Sud, Hospices Civiles de Lyon, 69000 Lyon, France
- Hélène Costaz
- Département d’Oncologie Chirurgicale, Centre Georges François Leclerc, Unicancer, 21000 Dijon, France
- Mathieu Mezzadri
- Service de Gynécologie Obstétrique, Hôpital Lariboisière, APHP, 75000 Paris, France
- Tristan Gauthier
- Service de Gynécologie Obstétrique, CHU de Limoges, 87000 Limoges, France
- Frederic Kridelka
- Service de Chirurgie Oncologique et Gynécologique, 4000 Liège, Belgique
- Pauline Chauvet
- Service de Gynécologie Obstétrique, CHU de Clermont Ferrand, 63000 Clermont Ferrand, France
- Nicolas Bourdel
- Service de Gynécologie Obstétrique, CHU de Clermont Ferrand, 63000 Clermont Ferrand, France
- Martin Koskas
- Service de Gynécologie, Hôpital Bichat, APHP, 75018 Paris, France
- Xavier Carcopino
- Service de Gynécologie, Hôpital La Timone, APHM, 13000 Marseille, France
- Emilie Raimond
- Service de Gynécologie, Hôpital Universitaire de Reims, 51000 Reims, France
- Olivier Graesslin
- Service de Gynécologie, Hôpital Universitaire de Reims, 51000 Reims, France
- Lise Lecointre
- Service de Gynécologie Obstétrique, CHU Hautepierre, 67000 Strasbourg, France
- Marcos Ballester
- Croix Saint Simon, Service de Chirurgie Gynécologique, 75000 Paris, France
- Cyrille Huchon
- Department of Gynecology, Centre Hospitalier de Poissy, 78000 Poissy, France
- Jean Levêque
- Department of Gynecology, Rennes University Hospital, Hôpital Sud, 35000 Rennes, France
- Vincent Lavoué
- Department of Gynecology, Rennes University Hospital, Hôpital Sud, 35000 Rennes, France
- DOI
- https://doi.org/10.3390/jcm9051451
- Journal volume & issue
-
Vol. 9,
no. 5
p. 1451
Abstract
Elderly women with ovarian cancer are often undertreated due to a perception of frailty. We aimed to evaluate the management of young, elderly and very elderly patients and its impact on survival in a retrospective multicenter study of women with ovarian cancer between 2007 to 2015. We included 979 women: 615 women (62.8%) p = 0.048). Patients >65 years had more >IIa FIGO stage: 76% for p = 0.033). Women ≥75 years had less standard procedures (40% (34/84) vs. 59% (104/177) for 65–74 years and 72% (384/530) for p 8 compared with 16% and 22% for the other groups (p p p = 0.003). Univariate analysis for 3-year Overall Survival showed that age >65 years, FIGO III (HR = 3.702, 95%CI: 2.30–5.95) and IV (HR = 6.318, 95%CI: 3.70–10.77) (p p p 65 years are more likely to have incomplete surgery and more residual disease despite more advanced ovarian cancer. These elements are prognostic factors for women’s survival regardless of age. Specific trials in the elderly would produce evidence-based medicine and guidelines for ovarian cancer management in this population.
Keywords