Evaluation of ten years of experience in managing patients with hepatic encephalopathy on the waiting list for liver transplantation in the Rostov region

Abstract

Objective is to analyze the clinical outcome of patients with varying degrees of hepatic encephalopathy (HE) on the waiting list for liver transplantation (LT) within one center. Materials and methods are clinical, laboratory and instrumental data of 847 patients from LT. A retrospective clinical and laboratory analysis of patients divided into 5 groups according to the clinical outcome in LT (delisting due to persistent recompensation of liver function, observation on the waiting list, delisting due to patient death, delisting due to orthotopic liver transplantation (OLT), as well as patients observed in the center, but not included in the Treatment data were evaluated and presented depending on the stage of hepatic encephalopathy. A retrospective analysis of the implementation of the organ transplantation program in our center showed that a prerequisite for reducing mortality in LP TP and developing an effective algorithm for monitoring patients from LP TP is the development of criteria for the priority and timeliness of measures to prevent PE, as well as systematic clinical and diagnostic monitoring of patients with various forms of PE in parallel with other manifestations of decompensation of liver function. Timely detection of HE and the urgent implementation of measures that stop PE and prevent its progression is a prerequisite for reducing mortality in LT.

Keywords

• liver transplantation
• liver cirrhosis
• hepatic encephalopathy