Sumoylation of RORγt regulates TH17 differentiation and thymocyte development

Zhiheng He; Jing Zhang; Zhaofeng Huang; Qian Du; Ning Li; Qiang Zhang; Yuan Chen; Zuoming Sun

doi:10.1038/s41467-018-07203-z

Nature Communications (Nov 2018)

Sumoylation of RORγt regulates TH17 differentiation and thymocyte development

Zhiheng He,
Jing Zhang,
Zhaofeng Huang,
Qian Du,
Ning Li,
Qiang Zhang,
Yuan Chen,
Zuoming Sun

Affiliations

Zhiheng He: Division of Molecular Immunology, Beckman Research Institute of City of Hope
Jing Zhang: Division of Molecular Immunology, Beckman Research Institute of City of Hope
Zhaofeng Huang: Zhongshan School of Medicine, Sun Yat-sen University
Qian Du: Division of Molecular Immunology, Beckman Research Institute of City of Hope
Ning Li: Department of Infectious Diseases, Huashan Hospital, Fudan Univerity
Qiang Zhang: Tianjin Medical University General Hospital, Tianjin Geriatrics Institute
Yuan Chen: Division of Molecular Medicine, Beckman Research Institute of City of Hope
Zuoming Sun: Division of Molecular Immunology, Beckman Research Institute of City of Hope

DOI: https://doi.org/10.1038/s41467-018-07203-z
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 18

Abstract

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The transcription factor RORγt is essential for the differentiation of TH17 cells, thymocyte development and lymphoid organogenesis. Here the authors show that the function of RORγt is regulated by PIAS4-mediated sumoylation that stabilize the interaction with SRC1 and KAT2A, to enhance the transcriptional activity of RORγt.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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