GAWMerge expands GWAS sample size and diversity by combining array-based genotyping and whole-genome sequencing

Ravi Mathur; Fang Fang; Nathan Gaddis; Dana B. Hancock; Michael H. Cho; John E. Hokanson; Laura J. Bierut; Sharon M. Lutz; Kendra Young; Albert V. Smith; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; Edwin K. Silverman; Grier P. Page; Eric O. Johnson

doi:10.1038/s42003-022-03738-6

Communications Biology (Aug 2022)

GAWMerge expands GWAS sample size and diversity by combining array-based genotyping and whole-genome sequencing

Ravi Mathur,
Fang Fang,
Nathan Gaddis,
Dana B. Hancock,
Michael H. Cho,
John E. Hokanson,
Laura J. Bierut,
Sharon M. Lutz,
Kendra Young,
Albert V. Smith,
NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium,
Edwin K. Silverman,
Grier P. Page,
Eric O. Johnson

Affiliations

Ravi Mathur: GenOmics, Bioinformatics, and Translational Research Center, RTI International
Fang Fang: GenOmics, Bioinformatics, and Translational Research Center, RTI International
Nathan Gaddis: GenOmics, Bioinformatics, and Translational Research Center, RTI International
Dana B. Hancock: GenOmics, Bioinformatics, and Translational Research Center, RTI International
Michael H. Cho: Channing Division of Network Medicine, Brigham and Women’s Hospital
John E. Hokanson: Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver
Laura J. Bierut: Department of Psychiatry, Washington University
Sharon M. Lutz: PRecisiOn Medicine Translational Research (PROMoTeR) Center, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care
Kendra Young: Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver
Albert V. Smith: Center for Statistical Genetics, University of Michigan
NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium
Edwin K. Silverman: Channing Division of Network Medicine, Brigham and Women’s Hospital
Grier P. Page: GenOmics, Bioinformatics, and Translational Research Center, RTI International
Eric O. Johnson: GenOmics, Bioinformatics, and Translational Research Center, RTI International

DOI: https://doi.org/10.1038/s42003-022-03738-6
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 9

Abstract

Read online

GAWMerge is a computational tool that allows users to integrate SNP genotyping data from array techniques or whole-genome sequencing, providing a feasible method to leverage existing cohorts to increase sample size in genetic studies.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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