Temporal dynamics of protein complex formation and dissociation during human cytomegalovirus infection

Yutaka Hashimoto; Xinlei Sheng; Laura A. Murray-Nerger; Ileana M. Cristea

doi:10.1038/s41467-020-14586-5

Nature Communications (Feb 2020)

Temporal dynamics of protein complex formation and dissociation during human cytomegalovirus infection

Yutaka Hashimoto,
Xinlei Sheng,
Laura A. Murray-Nerger,
Ileana M. Cristea

Affiliations

Yutaka Hashimoto: Department of Molecular Biology, Princeton University, Lewis Thomas Laboratory
Xinlei Sheng: Department of Molecular Biology, Princeton University, Lewis Thomas Laboratory
Laura A. Murray-Nerger: Department of Molecular Biology, Princeton University, Lewis Thomas Laboratory
Ileana M. Cristea: Department of Molecular Biology, Princeton University, Lewis Thomas Laboratory

DOI: https://doi.org/10.1038/s41467-020-14586-5
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 20

Abstract

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Here, Hashimoto et al. apply mass spectrometry-based thermal proximity coaggregation to characterize the temporal dynamics of virus-host protein-protein interactions during human cytomegalovirus (HCMV) infection, uncovering proviral functions including the internalization of the HCMV receptor integrin beta 1 with CD63.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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