New Data On Isopenicillin N Synthase And Peroxisome Co-Location In The Hyphal Cells Of Penicillium Chrysogenum PQ-96 – Pexophagy And Exocytosis

Kurzątkowski Wiesław; Górska Paulina; Główka Małgorzata; Woźnica Katarzyna; Zasada Aleksandra

doi:10.21307/PM-2019.58.1.080

Postępy Mikrobiologii (Jan 2019)

New Data On Isopenicillin N Synthase And Peroxisome Co-Location In The Hyphal Cells Of Penicillium Chrysogenum PQ-96 – Pexophagy And Exocytosis

Kurzątkowski Wiesław,
Górska Paulina,
Główka Małgorzata,
Woźnica Katarzyna,
Zasada Aleksandra

Affiliations

Kurzątkowski Wiesław: Department of Sera and Vaccines Evaluation, National Institute of Public Health – National Institute of HygienewarsawPoland
Górska Paulina: Department of Sera and Vaccines Evaluation, National Institute of Public Health – National Institute of HygienewarsawPoland
Główka Małgorzata: Department of Sera and Vaccines Evaluation, National Institute of Public Health – National Institute of HygienewarsawPoland
Woźnica Katarzyna: Department of Sera and Vaccines Evaluation, National Institute of Public Health – National Institute of HygienewarsawPoland
Zasada Aleksandra: Department of Sera and Vaccines Evaluation, National Institute of Public Health – National Institute of HygienewarsawPoland

DOI: https://doi.org/10.21307/PM-2019.58.1.080
Journal volume & issue: Vol. 58, no. 1
pp. 80 – 85

Abstract

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The machinery of antibiotic production by Penicillium chrysogenum PQ-96 is composed of co-located cytosolic and peroxisomal enzymes of the penicillin G biosynthesis pathway. Pexophagy and exocytosis should be currently considered as an alternative for penicillin G secretion from the mycelial cells. Penicillin G overproduction is a cellular detoxification process, protecting the mycelium from the toxicity of the antibiotic precursor.

Published in Postępy Mikrobiologii

ISSN: 0079-4252 (Print); 2545-3149 (Online)
Publisher: Sciendo
Country of publisher: Poland
LCC subjects: Science: Microbiology
Website: https://sciendo.com/journal/AM

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