Nature Communications (Oct 2019)
DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering
- Chiara Milanese,
- Cíntia R. Bombardieri,
- Sara Sepe,
- Sander Barnhoorn,
- César Payán-Goméz,
- Donatella Caruso,
- Matteo Audano,
- Silvia Pedretti,
- Wilbert P. Vermeij,
- Renata M. C. Brandt,
- Akos Gyenis,
- Mirjam M. Wamelink,
- Annelieke S. de Wit,
- Roel C. Janssens,
- René Leen,
- André B. P. van Kuilenburg,
- Nico Mitro,
- Jan H. J. Hoeijmakers,
- Pier G. Mastroberardino
Affiliations
- Chiara Milanese
- Department of Molecular Genetics, Erasmus University Medical Center
- Cíntia R. Bombardieri
- Department of Molecular Genetics, Erasmus University Medical Center
- Sara Sepe
- Department of Molecular Genetics, Erasmus University Medical Center
- Sander Barnhoorn
- Department of Molecular Genetics, Erasmus University Medical Center
- César Payán-Goméz
- Department of Molecular Genetics, Erasmus University Medical Center
- Donatella Caruso
- Department of Pharmacological and Biomolecular Sciences, University of Milan
- Matteo Audano
- Department of Pharmacological and Biomolecular Sciences, University of Milan
- Silvia Pedretti
- Department of Pharmacological and Biomolecular Sciences, University of Milan
- Wilbert P. Vermeij
- Princess Máxima Center for Pediatric Oncology
- Renata M. C. Brandt
- Department of Molecular Genetics, Erasmus University Medical Center
- Akos Gyenis
- Department of Molecular Genetics, Erasmus University Medical Center
- Mirjam M. Wamelink
- Department of Clinical Chemistry, VU University Medical Center
- Annelieke S. de Wit
- Department of Molecular Genetics, Erasmus University Medical Center
- Roel C. Janssens
- Department of Molecular Genetics, Erasmus University Medical Center
- René Leen
- Laboratory of Genetic Metabolic Diseases, Academic Medical Center
- André B. P. van Kuilenburg
- Laboratory of Genetic Metabolic Diseases, Academic Medical Center
- Nico Mitro
- Department of Pharmacological and Biomolecular Sciences, University of Milan
- Jan H. J. Hoeijmakers
- Department of Molecular Genetics, Erasmus University Medical Center
- Pier G. Mastroberardino
- Department of Molecular Genetics, Erasmus University Medical Center
- DOI
- https://doi.org/10.1038/s41467-019-12640-5
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
ERCC1 is involved in a number of DNA repair pathways including nucleotide excision repair. Here the authors showed that reduced transcription in Ercc1-deficient mouse livers and cells increases ATP levels, suppressing glycolysis and rerouting glucose into the pentose phosphate shunt that generates reductive stress.
