Cytotoxic Compounds from Aloe megalacantha

Negera Abdissa; Sebastian Gohlke; Marcel Frese; Norbert Sewald

doi:10.3390/molecules22071136

Molecules (Jul 2017)

Cytotoxic Compounds from Aloe megalacantha

Negera Abdissa,
Sebastian Gohlke,
Marcel Frese,
Norbert Sewald

Affiliations

Negera Abdissa: Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University, P.O. Box 100131, 33501 Bielefeld, Germany
Sebastian Gohlke: Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University, P.O. Box 100131, 33501 Bielefeld, Germany
Marcel Frese: Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University, P.O. Box 100131, 33501 Bielefeld, Germany
Norbert Sewald: Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University, P.O. Box 100131, 33501 Bielefeld, Germany

DOI: https://doi.org/10.3390/molecules22071136
Journal volume & issue: Vol. 22, no. 7
p. 1136

Abstract

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Phytochemical investigation of the ethyl acetate extract of the roots of Aloe megalacantha led to the isolation of four new natural products—1,8-dimethoxynepodinol (1), aloesaponarin III (2), 10-O-methylchrysalodin (3) and methyl-26-O-feruloyl-oxyhexacosanate (4)—along with ten known compounds. All purified metabolites were characterized by NMR, mass spectrometric analyses and comparison with literature data. The isolates were evaluated for their cytotoxic activity against a human cervix carcinoma cell line KB-3-1 and some of them exhibited good activity, with aloesaponarin II (IC50 = 0.98 µM) being the most active compound.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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