Contact inhibition controls cell survival and proliferation via YAP/TAZ-autophagy axis

Mariana Pavel; Maurizio Renna; So Jung Park; Fiona M. Menzies; Thomas Ricketts; Jens Füllgrabe; Avraham Ashkenazi; Rebecca A. Frake; Alejandro Carnicer Lombarte; Carla F. Bento; Kristian Franze; David C. Rubinsztein

doi:10.1038/s41467-018-05388-x

Nature Communications (Jul 2018)

Contact inhibition controls cell survival and proliferation via YAP/TAZ-autophagy axis

Mariana Pavel,
Maurizio Renna,
So Jung Park,
Fiona M. Menzies,
Thomas Ricketts,
Jens Füllgrabe,
Avraham Ashkenazi,
Rebecca A. Frake,
Alejandro Carnicer Lombarte,
Carla F. Bento,
Kristian Franze,
David C. Rubinsztein

Affiliations

Mariana Pavel: Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Cambridge Biomedical Campus
Maurizio Renna: Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Cambridge Biomedical Campus
So Jung Park: Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Cambridge Biomedical Campus
Fiona M. Menzies: Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Cambridge Biomedical Campus
Thomas Ricketts: Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Cambridge Biomedical Campus
Jens Füllgrabe: Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Cambridge Biomedical Campus
Avraham Ashkenazi: Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Cambridge Biomedical Campus
Rebecca A. Frake: Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Cambridge Biomedical Campus
Alejandro Carnicer Lombarte: Department of Physiology Development and Neuroscience, University of Cambridge
Carla F. Bento: Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Cambridge Biomedical Campus
Kristian Franze: Department of Physiology Development and Neuroscience, University of Cambridge
David C. Rubinsztein: Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Cambridge Biomedical Campus

DOI: https://doi.org/10.1038/s41467-018-05388-x
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 18

Abstract

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At high cell density or when plated on soft matrix, YAP/TAZ are redistributed from the nucleus to the cytosol, becoming transcriptionally inactive. Here the authors show that at high cell density, autophagosome formation is impaired due to reduced YAP/TAZ-dependent transcription of actomyosin genes

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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