Computational Fluid Dynamic Optimization of Micropatterned Surfaces: Towards Biofunctionalization of Artificial Organs

Abstract

Modifying surface topography to prevent surface-induced thrombosis in cardiovascular implants allows endothelialization, which is the natural thrombo-resistance of blood-contacting surfaces, and is deemed to be the only long-term solution for hemocompatible materials. We adapted a simulation framework to predict platelet deposition on a modified surface and developed an optimization strategy to promote endothelial retention and limit platelet deposition. Under supraphysiological bulk shear stress, a maximum of 79% linear coverage was achieved. This study concludes that the addition of microtrenches promotes endothelial retention and can be improved through the optimal selection of geometric parameters.

Keywords

• LVAD
• mechanical valves
• thrombosis
• endothelial cells
• hemocompatibility
• mechanical devices