THE INFLUENCE OF FACTORS PATHOGENICITY OF HELICOBACTECTER PYLORI CAGA, VACA, DUPA ON THE DEVELOPMENT OF ATROPHIC CHANGES IN THE MUCOUS MEMBRANE OF THE STOMACH IN DISEASES OF THE GASTROINTESTINAL TRACT IN CHILDREN

Abstract

Purpose: to identify the relationship between the development of atrophic changes of gastric mucosa and the presence of Helicobacter pylori pathogenicity factors in children with CGD. Materials and Methods: the study involved 96 children (8-14 years). All children were held esophagogastroduodenoscopy with biopsy mucosa antrum, histological examination of biopsy samples, diagnose H. pylori, genotyping of H. pylori. Results: in the group with atrophic changes characterized by a significantly higher percentage of H. pylori-positive patients, I serotype of H. pylori (CagA + and VacA +) and prevailed subtype VacAm1 (χ2: p <0,005), and in patients without atrophic changes in the coolant significantly more often determined VacAm2. Availability dupA gene is associated with a lower chance of atrophy. Summary: the relationships between the formation of atrophic changes of gastric mucosa and the presence of vacA, cagA, dupA Helicobacter pylori in children with chronic gastroduodenitis.

Keywords

• h. pylori
• pathogenicity factors
• chronic gastritis
• gastroduodenitis
• children