Nature Communications (Sep 2018)
Apolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis
- Xiaohong Ruby Xu,
- Yiming Wang,
- Reheman Adili,
- Lining Ju,
- Christopher M. Spring,
- Joseph Wuxun Jin,
- Hong Yang,
- Miguel A. D. Neves,
- Pingguo Chen,
- Yan Yang,
- Xi Lei,
- Yunfeng Chen,
- Reid C. Gallant,
- Miao Xu,
- Hailong Zhang,
- Jina Song,
- Peifeng Ke,
- Dan Zhang,
- Naadiya Carrim,
- Si-Yang Yu,
- Guangheng Zhu,
- Yi-Min She,
- Terry Cyr,
- Wenbin Fu,
- Guoqing Liu,
- Philip W. Connelly,
- Margaret L. Rand,
- Khosrow Adeli,
- John Freedman,
- Jeffrey E. Lee,
- Patrick Tso,
- Patrizia Marchese,
- W. Sean Davidson,
- Shaun P. Jackson,
- Cheng Zhu,
- Zaverio M. Ruggeri,
- Heyu Ni
Affiliations
- Xiaohong Ruby Xu
- Department of Laboratory Medicine and Pathobiology, University of Toronto
- Yiming Wang
- Department of Laboratory Medicine and Pathobiology, University of Toronto
- Reheman Adili
- Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, and Toronto Platelet Immunobiology Group
- Lining Ju
- Coulter Department of Biomedical Engineering, Georgia Institute of Technology
- Christopher M. Spring
- Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, and Toronto Platelet Immunobiology Group
- Joseph Wuxun Jin
- Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, and Toronto Platelet Immunobiology Group
- Hong Yang
- Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, and Toronto Platelet Immunobiology Group
- Miguel A. D. Neves
- Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, and Toronto Platelet Immunobiology Group
- Pingguo Chen
- Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, and Toronto Platelet Immunobiology Group
- Yan Yang
- Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, and Toronto Platelet Immunobiology Group
- Xi Lei
- Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, and Toronto Platelet Immunobiology Group
- Yunfeng Chen
- Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology
- Reid C. Gallant
- Department of Laboratory Medicine and Pathobiology, University of Toronto
- Miao Xu
- Department of Laboratory Medicine and Pathobiology, University of Toronto
- Hailong Zhang
- Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, and Toronto Platelet Immunobiology Group
- Jina Song
- Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, and Toronto Platelet Immunobiology Group
- Peifeng Ke
- Guangzhou University of Chinese Medicine
- Dan Zhang
- Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, and Toronto Platelet Immunobiology Group
- Naadiya Carrim
- Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, and Toronto Platelet Immunobiology Group
- Si-Yang Yu
- Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, and Toronto Platelet Immunobiology Group
- Guangheng Zhu
- Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, and Toronto Platelet Immunobiology Group
- Yi-Min She
- Centre for Biologics Research, Biologics and Genetic Therapies Directorate, HPFB, Health Canada
- Terry Cyr
- Centre for Biologics Research, Biologics and Genetic Therapies Directorate, HPFB, Health Canada
- Wenbin Fu
- Department of Acupuncture and Moxibustion, Guangdong Provincial Hospital of Chinese Medicine
- Guoqing Liu
- Institute of Cardiovascular Science, Peking University Health Science Center
- Philip W. Connelly
- Department of Laboratory Medicine and Pathobiology, University of Toronto
- Margaret L. Rand
- Department of Laboratory Medicine and Pathobiology, University of Toronto
- Khosrow Adeli
- Department of Laboratory Medicine and Pathobiology, University of Toronto
- John Freedman
- Department of Laboratory Medicine and Pathobiology, University of Toronto
- Jeffrey E. Lee
- Department of Laboratory Medicine and Pathobiology, University of Toronto
- Patrick Tso
- Department of Pathology and Laboratory Medicine, University of Cincinnati
- Patrizia Marchese
- Department of Molecular and Experimental Medicine, The Scripps Research Institute
- W. Sean Davidson
- Department of Pathology and Laboratory Medicine, University of Cincinnati
- Shaun P. Jackson
- Heart Research Institute, and Charles Perkins Centre, The University of Sydney
- Cheng Zhu
- Coulter Department of Biomedical Engineering, Georgia Institute of Technology
- Zaverio M. Ruggeri
- Department of Molecular and Experimental Medicine, The Scripps Research Institute
- Heyu Ni
- Department of Laboratory Medicine and Pathobiology, University of Toronto
- DOI
- https://doi.org/10.1038/s41467-018-05806-0
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 18
Abstract
Activation of integrin αIIbβ3 at the surface of platelets is required for their aggregation and for thrombus formation. Here Xu et al. identify apolipoprotein A-IV as a novel ligand for platelet αIIbβ3 integrin, and find it inhibits platelet aggregation and thrombosis.
