Primary intracerebral melanoma: A case report

Abstract

Primary intracranial malignant melanoma is an extremely rare entity These aggressive tumors are derived from the melanocytes of leptomeninges or their precursor cells and can give metastasis to other organs. It effects mostly middle aged males and represents a very poor prognosis with median survival less than 1 year. For proper diagnosis, melanoma of other localization must be excluded. Giving the rarity of this tumor, treatment of choice in unclear. We report a case of 43 year old patient with primary intracranial melanoma treated by supramarginal resection followed by whole brain RT, with disease free period of three years following treatment. We strongly advocate for aggressive treatment approach, supramarginal resection whenever safe, adjuvant therapy and frequent check-ups. We also hope to inspire future studies on larger sample to in order to establish an adequate therapy protocols.