Multi-omics analysis identifies therapeutic vulnerabilities in triple-negative breast cancer subtypes

Brian D. Lehmann; Antonio Colaprico; Tiago C. Silva; Jianjiao Chen; Hanbing An; Yuguang Ban; Hanchen Huang; Lily Wang; Jamaal L. James; Justin M. Balko; Paula I. Gonzalez-Ericsson; Melinda E. Sanders; Bing Zhang; Jennifer A. Pietenpol; X. Steven Chen

doi:10.1038/s41467-021-26502-6

Nature Communications (Nov 2021)

Multi-omics analysis identifies therapeutic vulnerabilities in triple-negative breast cancer subtypes

Brian D. Lehmann,
Antonio Colaprico,
Tiago C. Silva,
Jianjiao Chen,
Hanbing An,
Yuguang Ban,
Hanchen Huang,
Lily Wang,
Jamaal L. James,
Justin M. Balko,
Paula I. Gonzalez-Ericsson,
Melinda E. Sanders,
Bing Zhang,
Jennifer A. Pietenpol,
X. Steven Chen

Affiliations

Brian D. Lehmann: Department of Medicine, Vanderbilt University Medical Center
Antonio Colaprico: Department of Public Health Sciences, University of Miami Miller School of Medicine
Tiago C. Silva: Department of Public Health Sciences, University of Miami Miller School of Medicine
Jianjiao Chen: Department of Public Health Sciences, University of Miami Miller School of Medicine
Hanbing An: Department of Otolaryngology, Vanderbilt University Medical Center
Yuguang Ban: Department of Public Health Sciences, University of Miami Miller School of Medicine
Hanchen Huang: Department of Public Health Sciences, University of Miami Miller School of Medicine
Lily Wang: Department of Public Health Sciences, University of Miami Miller School of Medicine
Jamaal L. James: Department of Medicine, Vanderbilt University Medical Center
Justin M. Balko: Department of Medicine, Vanderbilt University Medical Center
Paula I. Gonzalez-Ericsson: Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center
Melinda E. Sanders: Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center
Bing Zhang: Lester and Sue Smith Breast Center, Baylor College of Medicine
Jennifer A. Pietenpol: Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center
X. Steven Chen: Department of Public Health Sciences, University of Miami Miller School of Medicine

DOI: https://doi.org/10.1038/s41467-021-26502-6
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 18

Abstract

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Triple negative breast cancer can be divided into additional subtypes. Here, using omics analyses, the authors show that in the mesenchymal subtype expression of MHC-1 is repressed and that this can be restored by using drugs that target subunits of the epigenetic modifier PRC2.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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