Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition

Jessica Gräb; Isabelle Suárez; Edeltraud van Gumpel; Sandra Winter; Fynn Schreiber; Anna Esser; Christoph Hölscher; Melanie Fritsch; Marc Herb; Michael Schramm; Laurens Wachsmuth; Christian Pallasch; Manolis Pasparakis; Hamid Kashkar; Jan Rybniker

doi:10.1038/s41467-019-08405-9

Nature Communications (Feb 2019)

Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition

Jessica Gräb,
Isabelle Suárez,
Edeltraud van Gumpel,
Sandra Winter,
Fynn Schreiber,
Anna Esser,
Christoph Hölscher,
Melanie Fritsch,
Marc Herb,
Michael Schramm,
Laurens Wachsmuth,
Christian Pallasch,
Manolis Pasparakis,
Hamid Kashkar,
Jan Rybniker

Affiliations

Jessica Gräb: Department I of Internal Medicine, University of Cologne
Isabelle Suárez: Department I of Internal Medicine, University of Cologne
Edeltraud van Gumpel: Department I of Internal Medicine, University of Cologne
Sandra Winter: Department I of Internal Medicine, University of Cologne
Fynn Schreiber: Department I of Internal Medicine, University of Cologne
Anna Esser: Department I of Internal Medicine, University of Cologne
Christoph Hölscher: German Center for Infection Research (DZIF), Partner Site Bonn-Cologne
Melanie Fritsch: Center for Molecular Medicine Cologne (CMMC), University of Cologne
Marc Herb: Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne
Michael Schramm: Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne
Laurens Wachsmuth: Institute for Genetics, University of Cologne
Christian Pallasch: Department I of Internal Medicine, University of Cologne
Manolis Pasparakis: Center for Molecular Medicine Cologne (CMMC), University of Cologne
Hamid Kashkar: Center for Molecular Medicine Cologne (CMMC), University of Cologne
Jan Rybniker: Department I of Internal Medicine, University of Cologne

DOI: https://doi.org/10.1038/s41467-019-08405-9
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

Read online

Corticosteroids are host-directed drugs that enhance survival of tuberculosis patients through unclear mechanisms. Here, Gräb et al. show that corticosteroids inhibit necrotic death of cells infected with Mycobacterium tuberculosis by facilitating MKP-1-dependent dephosphorylation of p38 MAPK.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal